个人信息
个人简介

    一九八一年毕业于苏州蚕桑专科学校(现并入苏州大学),二零零五月获日本信州大学大学院工学系研究科生物机能专业工学博士学位。现任苏州大学医学部生物物理专业硕士生导师,特种经济动物饲养专业和药物化学专业博士生导师。

十一五十二五十三五”期间连续被农业部聘任为《国家现代农业产业技术体系》蚕茧深加工利用/蚕丝资源综合利用岗位科学家。参与多个“973”重点项目和农业部公益项目研究,担任国家“863”重大项目《家蚕基因表达谱和蛋白质组研究》(2006AA10A118)课题组副组长。在国内外学术刊物上发表研究论文近200篇,其中有60多篇发表在SCI收录1区和2区等杂志上;有篇论文分别获得1994-95年度1996-97年度1998-99年度和2004-05年度苏州市自然科学优秀论文一等奖。申请中国发明专利、实用新型专利和国际专利30项;获省部级科学技术进步奖五项,2013年参加项目《丝胶回收与综合利用关键技术及产业化》获得国家科技进步二等奖(证书号: 2013-J-212-2-03-R05)。19992003200520072013年分别获苏州大学陆氏科研基金奖、苏州大学大陆产业基金奖、苏鑫奖教金科研奖和周氏科研类优胜奖。2010年评为苏州大学2010届毕业设计(论文)优秀指导老师,指导的3名硕士和1名博士研究生分别获得201420162017年度苏州大学优秀硕士和博士学位论文。2018年度获得江苏省优秀硕士学位论文[苏学位字(2018)11]


研究领域

1. 丝蛋白新功能材料与药物,包括丝蛋白作为酶/药物缓释载体、医用生物材料和生物药物等;

2. 蚕桑资源循环利用




基本信息
头像




张雨青

职称:教授

院部/部门:苏州医学院基础医学与生物科学学院

学历:博士

学位:

毕业学校:Shinshu University

毕业专业:

联系方式

通讯地址:独墅湖校区仁爱路199号702-2303室

邮政编码:215123

电子邮箱:sericult@suda.edu.cn

联系电话:65880181

传真号码:

办公地点:702-2303

科学研究
科研团队
论文
  • 1、

论文/Publications

106. Zhong, Z.-H., & Zhang, Yu-Qing*. (2023). Long-term preservation at low temperature of Escherichia coli cells embedded in egg white glass formed by slow drying at room temperature. Int J Biol Macromol, 225, 1129–1139. https://doi.org/10.1016/j.ijbiomac.2022.11.174

105. Wang, H.-D., & Zhang, Yu-Qing*. (2023). The glycation of silk sericin to enhance its application to functional foods. LWT - Food Sci Technol, 173, 114255. https://doi.org/10.1016/j.lwt.2022.114255

104. Jing, F.-Y., & Zhang, Yu-Qing*. (2022). Unidirectional Nanopore Dehydration Induces an Anisotropic Polyvinyl Alcohol Hydrogel Membrane with Enhanced Mechanical Properties. Gels, 8(803), 1–19. https://doi.org/10.3390/gels8120803

103. Zhong, Z.-H., & Zhang, Yu-Qing*.. (2022). Green immobilization and efficient proliferation of Escherichia coli cells in polyvinyl alcohol hydrogel membranes by unidirectional nanopore dehydration. Microbial Cell Factories, 21(264), 1–13. https://doi.org/10.1186/s12934-022-01995-y

102. Zhen-Zhen Wei, Xiau Dong and Yu-Qing Zhang*. A mechanically robust egg white hydrogel scaffold with excellent biocompatibility by three-step green processing. Science China Technological Sciences 2022, 65(7): 1599-1612. DOI: 10.1007/s11431-022-2039-2

101. Feng-Ya Jing, Yu-Jie Weng, Yu-Qing Zhang*. The protective effect of sericin on AML12 cells exposed to oxidative stress damage in a high-glucose environment. Antioxidants 2022, 11, 712(1-12). DOI: 10.3390/anti11040712

100. Zhen-Zhen Wei, Yu-Jie Weng and Yu-Qing Zhang*. Investigation of repairing effect and mechanism of oral degraded sericin on liver injury in type II diabetic rats. Biomolecules 2022,12(3): 444(1-12). DOI: 10.3390/biom12030444

99. Zhen-Zhen Wei, Yu-Jie Weng and Yu-Qing Zhang*. Enhanced the in vitro biological activity of the degraded silk sericin and its analog metabolites. Biomolecules 2022,12(2): 161(1-12). DOI: 10.3390/biom12020161

98. Ji-Xin Li, Shu-Xiang Zhao and Yu-Qing Zhang*. Silk Protein Composite Bioinks and Their 3D Scaffolds and In Vitro Characterization. International Journal of Molecular Sciences 2022,23(2): 910(1-18). DOI: 10.3390/ijms23020910

97. Hai-Yan Wang, Su-Fang Zhou, Meng Zhang, Heng-Da Wang, Yu-Qing Zhang* The post-processing temperature or humidity can importantly control the secondary structure and characteristics of silk fibroin films. Journal of Biomedical Materials Research A 2022, 110(4):827-837

96. Hai-Yan Wang, Yu-Qing Zhang*, Zheng-Guo Wei* Characterization of undegraded and degraded silk fibroin and its significant impact on the properties of the resulting silk biomaterials. International Journal of Biological Macromolecules 2021, 176: 578–588

95. Wang, H.-Y.,Zhe-Guo Wei* and Yu-Qing Zhang* Dissolution and processing of silk fibroin for materials science. Critical Reviews in Biotechnology 2021, 41(3): 406-424. DOI: 10.1080/07388551.2020.1853030

94. Heng-Da Wang, Zhi-Hao Zhong, Yu-Jie Weng, Zhen-Zhen Wei, Yu-Qing Zhang* Degraded sericin significantly regulates blood glucose levels and improves impaired liver function in T2D rats by reducing oxidative stress. Biomolecules 2021,11(9), 1255,1-21

93. Yu-Jie Weng, Jiang Wang, Yu-Qing Zhang* Significantly hypoglycemic effect of a novel functional bread rich in mulberry bark and improving the related functions of liver, pancreas, and kidney, on T2D mice. Food Science and Nutrition 2021, 9(5): 2468-2482

92. Feng-Ya Jing, Yu-Zhen Zhou, Hai-Yan Wang, Xiao-Lu Yin, Yu-Qing Zhang* Enhancing antioxidant and anti-hyperglycaemic functions of Gingko Biloba L. seeds using thermal detoxification. Journal of Functional Foods 2021, 87: 104819

91. Zhen-Zhen Wei, Ji-Xin Li, Xiao-Lu Yin and Yu-Qing Zhang*. The anti-hyperglycaemia effects of functional bread containing sericin and mulberry bark powder from sericulture waste. Journal of Biobased Materials and Bioenergy 2021, 15(6):723-730

90. Xuan Dong, and Yu-Qing Zhang* An insight on egg white: From most common functional food to biomaterial application. Journal of Biomedical Materials Research B. 2021, 109(7): 1045-1058

89. Meng Wang#, Yu-Jie Weng#, Yu-Qing Zhang* Accelerated desalting and purification of silk fibroin in a CaCl2-EtOH-H2O ternary system by excess isopropanol extraction. Journal of Chemical Technology and Biotechnology 2021; 96: 1176–1186. DOI: 10.1002/jctb.6629

88. Xuan Dong, and Yu-Qing Zhang*. (2020) An insight on egg white: from most common functional food to biomaterial application. Journal of Biomedical Material Research B. on line. DOI: 10.1002/jbm.b.34768

87. Wang H-Y, Zhao J-G, Zhang Y-Q*. (2020) The flavonoid-rich ethanolic extract from the green cocoon shell of silkworm has excellent antioxidation, glucosidase inhibition, and cell protective effects in vitro. Food & Nutrition Research 64:1637(1-12). DOI:10.29219/fnr.v64.1637

86. Wang, H.-Y., Wei*, Z.-Q., & Zhang Y-Q*. (2020). Dissolution and regeneration of silk from silkworm Bombyx mori in ionic liquids and its application to medical biomaterials. International Journal of Biological Macromolecules 143, 594–601. DOI:10.1016/j.ijbiomac.2019.12.066

85. Wang, H.-Y., Zhang Y-Q*, & Wei, Z-G. (2020). Excess acetone extraction in silk protein solution greatly accelerates the regeneration progress of silk fibroin for desalting and purification. International Journal of Biological Macromolecules 146, 588–595. DOI:10.1016/j.ijbiomac.2019.12.274

84. Zhao, Z.-L., & Zhang, Y.-Q*. (2020). Greener degumming production of layered sericin peptides from a silkworm cocoon and their physicochemical characteristics and bioactivityies in vitro. Journal of Cleaner Production, 261,121080 (1-10). DOI: 10.1016/j.jclepro.2020.121080

83. Dong, X., Zhao, S., Yin, X., Wang, H., Wei, Z., & Zhang, Y.-Q*. (2020). Silk sericin has significantly hypoglycaemic effect in type 2 diabetic mice via anti-oxidation and anti-inflammation. International Journal of Biological Macromolecules 150(1), 1061-1071. DOI:10.1016/j.ijbiomac.2019.10.111

82. Zhang, M., Zhao, S., Ding, B., & Zhang, Y.-Q*. (2020). Sodium N-lauryl amino acids derived from silk protein can form catanionic aggregates with cytarabine as novel anti-tumor drug delivery systems. Drug Delivery, 27(1), 482-490. DOI:10.1080/10717544.2020.1742250

81. Xuan Dong, Bing-Qing Xu and Yu-Qing Zhang*. G. divaricata ameliorates hepatic insulin resistance by modulating insulin signalling, maintaining glycolipid homeostasis and reducing inflammation in T2DM. Toxicology Research 2019, 8: 928-938. DOI:10.1039/C9TX00191C.

80. Wang, H.-Y., Jin-Ge Zhao and Yu-Qing Zhang*. The renal protection of flavonoid-rich ethanolic extract from silkworm green cocoon involves in inhibiting TNF-α-p38 MAP kinase signalling pathway in type 2 diabetic mice. Biomedicine & Pharmacotherapy 2019, 118: 109379. DOI:10.1016/j.biopha.2019.109379

79. Wang, H.-Y., and Yu-Qing Zhang*.The main active constituents and detoxification process of Ginkgo biloba seeds and their potential use in functional health foods. Journal of Food Composition and Analysis. 2019, 83: 103247. DOI:10.1016/j.jfca.2019.103247

78. Meng Zhang, Dong Liu and Yu-Qing Zhang*. Rapid analysis of the bioactive components in Saxifraga stolonifera, an edible and medicinal herb with anti-tumor effects, by HPLC-DAD, ESI/MSn. Journal of Applied Botany and Food Quality. 2019, on line. DOI:10.5073/JABFQ.2019.092.00X

77. Jin-Ge Zhao, Wang, H.-Y., and Yu-Qing Zhang*. Therapeutic effect of ethanolic extract from the green cocoon shell of silkworm Bombyx mori on type 2 diabetic mice and its hypoglycaemic mechanism. Toxicology Research. 2019, 8:407-420. DOI:10.1039/c8tx00294k

76. Meng Zhang, Ting-Ting Cao, Zheng-Guo Wei* and Yu-Qing Zhang**. Silk Sericin Hydrolysate is a Potential Candidate as a Serum-Substitute in the Culture of Chinese Hamster Ovary and Henrietta Lacks Cells. Journal of Insect Science. 2019, 9(1):10, 1-12. DOI:10.1093/jisesa/iey137

75. Fan Qiu; Yu-Qing Zhang*. Metabolic effects of mulberry branch bark powder on diabetic mice based on GC-MS metabolomics approach. Nutrition & Metabolism. 2019, 16: 10, 1-16. DOI:10.1186/s12986-019-0335-x

74. Fan Qiu, Jiang Wang, Hua-Yu Liu, Yu-Qing Zhang*. Mulberry bark alleviates effect of STZ inducing diabetic mice through negatively regulating FoxO1. Evidence-Based Complementary and Alternative Medicine. 2019, 2182865: 1-9. DOI:10.1155/2019/2182865

73. Zhang, Yu-Qing. Preparation of Silk Fibroin Nanoparticles and Enzyme-Entrapped Silk Fibroin Nanoparticles. Bio-protocol. 2018, 8(24): 1-5. DOI:10.21769/BioProtoc.3113

8. Zhang, Yu-Qing. SDS-PAGE for Silk Fibroin Protein. Bio-protocol. 2018, Bio101: e3054. DOI:10.21769/BioProtoc.3054.

72. Xiao-Lu Yin, Bing-Qing Xu and Yu-Qing Zhang*. Gynura divaricata rich in 3, 5-/4, 5-dicaffeoylquinic acid and chlorogenic acid restrains islet cell apoptosis and improves pancreatic function in type 2 diabetic mice. Nutrition & Metabolism. 2018, 15:73(1-14). DOI:10.1186/s12986-018-0310-y

71. Lin Zhu, De-Qing Zou, Zuo-Qing Fan, Na Wang, Ying-Ying Bo, Yu-Qing Zhang*. Properties of a novel carboxymethyl chitosan derived from silkworm pupa. Archives of Insect Biochemistry and Physiology. 2018, 99: e21499. DOI:10.1002/arch.21499

70. Xiao-Lu Yin, Yi Lv, Yu-Qing Zhang*. Morusin suppresses A549 cell migration and induces cell apoptosis by down-regulating expression of COX-2 and VEGF. Oncology Reports. 2018, 40: 504-510. DOI:10.3892/or.2018.6431

69. Jin-Ge Zhao and Yu-Qing Zhang*. A novel estimation method of total flavonoids in an edible medicinal mulberry leaves by ultrasound-assisted hydroalcohol-acid extraction and HPLC-DAD. Journal of Applied Botany and Food Quality. 2018, 91: 114-119. DOI:10.5073/JABFQ.2018.091.016

68. Zhi-Lin Zhao; Li, Wen-Wen; Wang, Fei; & Zhang, Y-Q*. Using of hydrated lime water as a novel degumming agent of silk and sericin recycling from wastewater. Journal of Cleaner Production. 2018, 172: 2090-2096. DOI:10.1016/j.jclepro.2017.11.213

67. Xiao-LuYin, Hua-Yu Liu, Yu-Qing Zhang*. Oral administration of mulberry branch bark powder improves significantly hyperglycemia and hyperinsulinemia in type II diabetic mice. Food & Nutrition Research. 2017, 61(1): 1368847. DOI:10.1080/16546628.2017.1368847

66. Ting-Ting Cao, Yu-Qing Zhang*. The potential of silk sericin protein as a serum substitute in cell culture and cryopreservation. Amino Acids. 2017, 49(6): 1029-1039. DOI:10.1007/s00726-017-2396-3

65. Li, Wen-Wen, Wang, H., & Zhang, Y-Q*. A novel chitosan hydrogel membrane by an improved electrophoretic deposition and its characteristics in vivo and in vitro. Materials Science and Engineering C. 2017, 74: 287–297. DOI:10.1016/j.msec.2016.12.005

64. Fei Wang, Yu-Qing Zhang*. Effects of alkyl polyglycoside (APG) on Bombyx mori silk degumming and the mechanical properties of silk fibroin fibre. Materials Science and Engineering C. 2017, 74: 152–158. DOI:10.1016/j.msec.2017.02.015

63. Dong Liu, Yu-Qing Zhang*. Lung inflammation caused by long-term exposure to titanium dioxide in mice involving in NF-κB signaling pathway. Journal of Biomedical Material Research A. 2017, 105(3): 720–727. DOI:10.1002/jbm.a.35945

62. Biao Ding, Liang-Ze Wan,Yu-Qing Zhang*. Biosafety evaluation of three sodium lauryl N-amino acids synthesized from silk industrial waste in mice. Journal of Surfactants and Detergents. 2017, 20(5), 1173-1187. DOI:10.1007/s11743-017-1995-z

61. Jiang Wang, Li-Jun Zhao, Yu-Qing Zhang*. UV irradiation and salicylic acid immersion enhance the level of mulberroside A in isolated mulberry branches, a huge amount of agro-waste. Waste and Biomass Valorization. 2017, 8(8): 2643-2651. DOI:10.1007/s12649-016-9702-2

60. Bing-Qing Xu and Yu-Qing Zhang*. Bioactive components of Gynura divaricata and its potential use in health, food and medicine: a mini-review. African Journal of Traditional Complementary and Alternative Medicines. 2017, 14(3): 113-127. DOI:10.21010/ajtcam. v14i3.12

59. Hong, F*., Yu, X., & Zhang, Y.-Q*. Progress of in vivo studies on the systemic toxicities induced by titanium dioxide nanoparticles. Toxicology Research. 2017, 6, 115–133. DOI:10.1039/c6tx00338a

58. Yu, Xiaohong; Hong, Fashui*; Zhang, Yu-Qing*. Cardiac inflammation involving in PKCε or ERK1/2 -activated NF-κB signalling pathway in mice following exposure to titanium dioxide nanoparticles. Journal of Hazardous Materials. 2016, 313, 68–77. DOI:10.1016/j.jhazmat.2016.03.088

57. Yu, Xiaohong; Hong, Fashui*; Zhang, Yu-Qing*. Bio-effect of nanoparticles in the cardiovascular system. Journal of Biomedical Material Research A. 2016, 104A(11), 2881–2897. DOI:10.1002/jbm.a.35804

56. Jie Hong, Fashui Hong*, Yuguan Ze, Yu-Qing Zhang*. The nano-TiO2 exposure can induce hepatic inflammation involving in a JAK–STAT signalling pathway. Journal of Nanoparticles Research. 2016, 18, 162(9). DOI:10.1007/s11051-016-3472-4

55. Hua-Yu Liu, Jiang Wang,Jing Ma, Yu-Qing Zhang*. Interference effect of oral administration of mulberry branch bark powder on the incidence of type II diabetes in mice induced by streptozotocin. Food & Nutrition Research. 2016, 60, 31606(11). DOI:10.3402/fnr.v60.31606

54. Jin-Ge Zhao and Yu-Qing Zhang*. A new estimation of the total flavonoids in silkworm cocoon sericin layer through aglycone determination by hydrolysis-assisted extraction and HPLC-DAD analysis. Food & Nutrition Research. 2016, 60, 30932. DOI:10.3402/fnr.v60.30932

53. Jie Hong, Yu-Qing Zhang*. The murine liver damage caused by exposure to nano-titanium dioxide. Nanotechnology. 2016, 27, 112001. DOI:10.1088/0957-4484/27/11/112001

52. Ting-Ting Cao & Yu-Qing Zhang*. Processing and characterization of silk sericin from Bombyx mori and its application in biomaterials and biomedicines. Materials Science and Engineering C. 2016, 61, 940–952. DOI:10.1016/j.msec.2015.12.082

51. Lin Zhu, Yu-Qing Zhang*. Postoperative anti-adhesion ability of a novel carboxymethyl chitosan from silkworm pupa in a rat cecal abrasion model. Materials Science and Engineering C. 2016, 61, 387–395. DOI:10.1016/j.msec.2015.12.080

50. Biao Ding, Yi Lv, Shu Wang, Yu-Qing Zhang*. Anti-tumor effect of morusin from the branch bark of cultivated mulberry in Bel-7402 cells via the MAPK pathway. RSC Advances. 2016, 6, 17396–17404. DOI:10.1039/C5RA21321E

49. Dong Liu, Ping Yang, Yu-Qing Zhang*. Water-soluble extract of Saxifraga stolonifera has anti-tumor effects on Lewis lung carcinoma-bearing mice. Bioorganic & Medicinal Chemistry Letters. 2016, 26(19), 4671–4678. DOI:10.1016/j.bmcl.2016.08.051

48. Fan Qiu, Tian-Zhen He, Yu-Qing Zhang*. The isolation and the characterization of two polysaccharides from the branch bark of mulberry (Morus alba L.). Archives of Pharmacal Research. 2016, 39(5), 887–896. DOI:10.1007/s12272-016-0742-8

47. Bing-Qing Xu, Ping Yangand Yu-Qing Zhang*. Hypoglycemic activities of lyophilized powder of Gynura divaricata by improving antioxidant potential and insulin signaling in type 2 diabetic mice. Food & Nutrition Research. 2015, 59, 29652. DOI:10.3402/fnr.v59.29652

46. Fei Wang, Ting-Ting Cao & Yu-Qing Zhang*. Effect of silk protein surfactant on silk degumming and its properties. Materials Science and Engineering C. 2015, 55, 131–136. DOI:10.1016/j.msec.2015.05.041

45. Jin-Ge Zhao and Yu-Qing Zhang*. Inhibition of the flavonoid extract from silkworm cocoons on DMBA/UVB-induced skin damage and tumor promotion in BALB/C mouse. Toxicology Research. 2015, 4, 1016–1024. DOI:10.1039/C5TX00087D

44. Ting-Ting Cao & Yu-Qing Zhang*. Viability and proliferation of L929, tumour and hybridoma cells in the culture media containing sericin protein as a supplement or serum substitute. Applied Microbiology Biotechnology. 2015, 99(17), 7219–7228. DOI:10.1007/s00253-015-6576-3

43. Wang, H.-Y., Chen Y-Y & Zhang, Y.-Q*. Processing and characterization of powdered silk micro- and nanofibers by ultrasonication. Materials Science and Engineering C. 2015, 48, 444–452. DOI:10.1016/j.msec.2014.12.028

42. Wang, H., & Zhang, Y-Q*. Processing silk hydrogel and its applications in biomedical materials. Biotechnology Progress. 2015, 31(3), 630–640. DOI:10.1002/btpr.2058

41. Lin Zhu, Lin Peng and Yu-Qing Zhang*. The Processing of Chitosan and Its Derivatives and Their Application for Postoperative Anti-Adhesion. Mini-Reviews in Medicinal Chemistry. 2015, 15(4), 330–337. DOI:10.2174/1389557515666150227110547

40. Fei Wang and Yu-Qing Zhang*. Bioconjugation of Silk Fibroin Nanoparticles with Enzyme and Peptide and Their Characterization. Advances in Protein Chemistry and Structural Biology. 2015, 98, 263–291. DOI:10.1016/bs.apcsb.2014.11.005

39. Wang, H., & Zhang, Y-Q*. Processing and characterisation of a novel electropolymerized silk fibroin hydrogel membrane. Scientific Reports. 2014, 4, 6182. DOI:10.1038/srep06182

38. Min-Hui Wu, Liang-Ze Wan and Yu-Qing Zhang*. A novel sodium N-fatty acyl amino acid surfactant using silkworm pupae as stock material. Scientific Reports. 2014, 4, 4428. DOI:10.1038/srep04428

37. Jin-Ge Zhao, Qian-Qian Yan, Jian Zhang, Yu-Qing Zhang*. Isolation and identification of colorless caffeoyl compounds in purple sweet potato by HPLC-DAD-ESI/MS and their antioxidant activities. Food Chemistry. 2014, 161, 22–26. DOI:10.1016/j.foodchem.2014.03.079

36. Min-Hui Wu, and Yu-Qing Zhang*. Ultrafiltration recovery of sericin from silk floss processing alkaline waste and its controlled enzymatic hydrolysis. Journal of Cleaner Production. 2014, 76, 154–160. DOI:10.1016/j.jclepro.2014.03.068

35. Min-Hui Wu and Yu-Qing Zhang*. Nanofiltration recovery of sericin from silk processing waste and synthesis of a lauroyl sericinbased surfactant and its characteristics. RSC Advances. 2014, 4, 4140–4145. DOI:10.1039/c3ra45549a

34. Shu Wang, Xian-Ming Liu, Jian Zhang* and Yu-Qing Zhang*. An efficient preparation of mulberroside A from the branch bark of mulberry and its effect on the inhibition of tyrosinase activity. PLOS One. 2014, 9(10), e109396. DOI:10.1371/journal.pone.0109396

33. Liang-Ze Wan, Bin Ma and Yu-Qing Zhang*. Preparation of morusin from Ramulus mori and its effects on mice with transplanted H22 hepatocarcinoma. BioFactors. 2014, 40(6), 636–645. DOI:10.1002/biof.1191

32. Ting-Ting Cao, Zhen-Zhen Zhou and Yu-Qing Zhang*. Processing of b-glucosidase-silk fibroin nanoparticle bioconjugates and their characteristics. Applied Biochemistry and Biotechnology. 2014, 173, 544–551. DOI:10.1007/s12010-014-0861-y

31. Shu Wang, Meng Fang, Yong-Lei Ma, and Yu-Qing Zhang*. Preparation of the branch bark ethanol extract in mulberry Morus alba, its antioxidation, and antihyperglycemic activity in vivo. Evidence-Based Complementary and Alternative Medicine. 2014, 2014, 569652/7. DOI:10.1155/2014/569652

30. Liu, H., Fang, M., & Zhang, Y-Q*. .In Vivo Hypoglycaemic Effect and Inhibitory Mechanism of the Branch Bark Extract of the Mulberry on STZ-Induced. Scientific World Journal. 2014, 2014, 614265/1–11. DOI:10.1155/2014/614265

29. Lin Zhu, Yu-Qing Zhang*. Identification and analysis of the pigment composition and sources in the colored cocoon of the silkworm, Bombyx mori, by HPLC-DAD. Journal of Insect Science. 2014, 14, 31. DOI:10.1093/jis/14.1.31

28. Ting-Ting Cao, Yuan-Jing Wang and Yu-Qing Zhang*. Silk reeling of silkworm cocoon in strongly alkaline electrolyzed water as a sericin swelling agent at a lower temperature. The Journal of The Textile Institute. 2014, 105(5), 502–508. DOI:10.1080/00405000.2013.826418

27. Hai-Yan Wang, Yu-Qing Zhang*. Effect of regeneration of liquid silk fibroin on its structure and characterization. Soft Matter. 2013, 9, 138–145. DOI:10.1039/c2sm26945g

26. Ting-Ting Cao, Yuan-Jing Wang and Yu-Qing Zhang*. Effect of strongly alkaline electrolyzed water on silk degumming and the physical properties of the fibroin fiber. PLOS One. 2013, 8(6), e65654. DOI:10.1371/journal.pone.0065654

25. Jin-Ge Zhao, Qian-Qian Yan, Li-Zhen Lu and Yu-Qing Zhang*. In vivo antioxidant, hypoglycemic, and anti-tumor activities of anthocyanin extracts from purple sweet potato. Nutrition Research and Practice. 2013, 7(5), 359–365. DOI:10.4162/nrp.2013.7.5.359

24. Bin Ma, Fen-Ying Cui, Yu-Qing Zhang*. Rapid analysis of morusin from Ramulus mori by HPLC-DAD, its distribution in vivo and differentiation in the cultivated mulberry species. Food & Nutrition Sciences. 2013, 4(2), 189–194. DOI:10.4236/fns.2013.42026

23. Li-Jun Zhao and Yu-Qing Zhang*. Rapid analysis of oxyresveratrol-4-3'-β-O-D-diglycoside in branch bark of mulberry by HPCE-DAD. Advances in Biomedical Engineering Research. 2013, 4(1), 69–74. http://www.seipub.org/ABER/paperInfo.aspx?ID=10154

22. Min-Hui Wu, Lin Zhu, Zhen-Zhen Zhou, and Yu-Qing Zhang*. Coimmobilization of Naringinases on Silk Fibroin Nanoparticles and Its Application in Food Packaging. Journal of Nanoparticles. 2013, 2013, 901401. DOI:10.1155/2013/901401

21. Hai-Yan Wang, Yuan-Jing Wang Li-Xia Zhou, Lin Zhu and Yu-Qing Zhang*. Isolation and bioactivities of a non-sericin component from cocoon shell silk sericin of the silkworm Bombyx mori. Food & Function. 2012, 3(2), 150–158. DOI:10.1039/c1fo10148j

20. Meng Fang, An-Qing Huang and Yu-Qing Zhang*. The correlation between 1-deoxynojirimycin content and a-glucosidase inhibitory activity in the bark ethanol extract from Ramulus mori. IEEE Xplore. 2012, 1795–1798. DOI:10.1109/iCBEB.2012.406

19. Lin Zhu, Ren-Ping Hu, Hai-Yan Wang, Yuan-Jing Wang and Yu-Qing Zhang*. Bioconjugation of neutral protease on silk fibroin nanoparticles and application in the controllable hydrolysis of sericin. Journal of Agricultural and Food Chemistry. 2011, 29(18), 10298–10302. DOI:10.1021/jf202036v

18. Yu-Qing Zhang*, Yuan-Jing Wang, Hai-Yan Wang, Lin Zhu and Zhen-Zhen Zhou. Highly efficient processing of silk fibroin nanoparticle-L-asparaginase bioconjugates and their characterization as a drug delivery system. Soft Matter. 2011, 20, 9728–9736. DOI:10.1039/c0sm01332c

17. Zhen-Zhen Zhou and Yu-Qing Zhang*. Biosynthesis of beta-glucosidase-silk fibroin nanoparticles conjugates and enzymatic characteristics. Advanced Materials Research. 2011, 175-176, 186–191. DOI:10.4028/www.scientific.net/AMR.175-176.186

16. Yuan-Jing Wang and Yu-Qing Zhang*. Three-layered sericins around the silk fibroin fiber from Bombyx mori cocoon and their amino acid composition. Advanced Materials Research. 2011, 175-176, 158–163. DOI:10.4028/www.scientific.net/AMR.175-176.158

15. Li-Zhen Lu, Yu-Zhen Zhou, Yu-Qing Zhang*, Yong-Lei Ma, Li-Xia Zhou, Lin Li, Tian-Zhen He and Zhen-Zhen Zhou. Anthocyanin extracts from purple sweet potato by means of microwave baking and acidified electrolyzed water and their antioxidation in vitro. International Journal of Food Science and Technology. 2010, 45(7), 1378–1385. DOI:10.1111/j.1365-2621.2010.02271.x

14. ZHANG YuQing*, YU XiaoHua, SHEN WeiDe, MA YongLei, ZHOU LiXia, XU NaiXi & YI ShuQian. Mechanism of fluorescent cocoon sex identification for silkworms Bombyx mori. Science China Life Sciences. 2010, 53(11), 1330–1339. DOI:10.1007/s11427-010-4084-3

13. Hai-Bo Yan, Yu-Qing Zhang*, Yong-Lei Ma and Li-Xia Zhou. Biosynthesis of insulin-silk fibroin nanoparticles conjugates and in vitro evaluation of a drug delivery system. Journal of Nanoparticle Research. 2009, 11(8), 1937–1946. DOI:10.1007/s11051-008-9549-y

12. 张雨青*、相入丽、阎海波、陈晓晓.丝素纳米颗粒的制备及应用于L-天冬酰胺酶的固定化. 高等学校化学学报. 2008, 29(3), 628–63. DOI:10.3321/j.issn:0251-0790.2008.03.039

11. Yu-Qing Zhang*, Wei-De Shen, Ru-Li Xiang, Lan-Jian Zhuge, Wei-Jian Gao and Wen-Bao Wang. Formation of silk fibroin nanoparticles in water-miscible organic solvent and their characterization. Journal of Nanoparticle Research. 2007, 9(5), 885–900. DOI:10.1007/s11051-006-9162-x

10. Yu-Qing Zhang*, Yan Ma, Yun-Yue Xia, Wei-De Shen and Jian-Ping Mao, Xin-Min Zha, Koji Shirai and Kenji Kiguchi. Synthesis of silk fibroin-insulin bioconjugates and their characterization and activities in vivo. Journal of Biomedical Material Research B. 2006, 79B: 275-283. DOI:10.1002/jbm.b.30539

9.Yu-Qing Zhang*, Mei-Lin Tao, Wei-De Shen, Jian-Ping Mao and Yu-hua Chen. Synthesis of silk sericin peptides-L-asparaginase bioconjugates and their characterization. Journal of Chemical Technology and Biotechnology. 2006, 81(2): 136-145. DOI:10.1002/jctb.1370

8. Yu-Qing Zhang*, Yan Ma, Yun-Yue Xia, Wei-De Shen and Jian-Ping Mao. Silk sericin-insulin bioconjugates: synthesis, characterization and biological activity. Journal of Controlled Release. 2006, 115(3): 307-315. DOI:10.1016/j.jconrel.2006.08.019

7. Yu-Qing Zhang*, Wen-Lin Zhou, Wei-De Shen, Yu-hua Chen, Xin-Min Zha, Koji Shirai and Kenji Kiguchi. Synthesis, characterization and immunogenicity of silk fibroin-L-asparaginase bioconjugates. Journal of Biotechnology. 2005, 120(3): 315-326. DOI:10.1016/j.jbiotec.2005.06.027

6. Yu-Qing Zhang*, Mei-Lin Tao, Wei-De Shen, Yu-Zhen Zhou, Yue Ding, Yan Ma, Wen-Lin Zhou. Immobilization of L-asparaginase on the microparticles of the natural silk sericin protein and its characters. Biomaterials. 2004, 25: 3751-3759. DOI:10.1016/j.biomaterials.2003.10.019

5. Yu-Qing Zhang. Applications of natural silk protein sericin in biomaterials. Biotechnology Advances. 2002, 20: 91-100. DOI:10.1016/S0734-9750(02)00003-4

4. Yu-Qing Zhang*; Gu, Ren-Ao; Shen, Wei-De and Zhen, Xiao-Jian.Application of an ion pair reagent to biosensors. Analytical Letters. 1999, 32: 251-269. DOI:10.1080/00032719908542819

3. Yu-Qing Zhang. Natural silk fibroin as a support for enzyme immobilization. Biotechnology Advances. 1998, 16: 961-971. DOI:10.1016/S0734-9750(98)00012-3

2. Zhang, Yu-Qing*; Shen, Wei-De; Gu, Ren-Ao; Zhu, Jiang and Xue, Ren-Yu. Amperometric biosensor for uric acid based on uricase-immobilized silk fibroin membrane. Analytica Chimica Acta. 1998, 369(1/2): 123-128. DOI:10.1016/S0003-2670(98)00236-0

1. Zhang, Yu-Qing*; Zhu, Jiang and Gu, Ren-Ao. Improved biosensor for glucose based on glucose oxidase-immobilized silk fibroin membrane. Applied Biochemistry and Biotechnology. 1998, 75(2/3): 215-233. DOI:10.1007/BF02787776

专利/Patents

1. 张雨青、李文文、王飞,一种蚕丝脱胶/精练剂、应用及对脱胶废液的处理方法,发明专利, CN20161114203922016-12-12

2. 张雨青、赵金鸽,一种蚕茧层活性物质总黄酮的评价方法,中国专利,CN20161042756762016-6-16

3. 张雨青、殷晓路,一种用于连接不同口径的玻璃磨口的转接器,实用新型专利,CN2016212310094, 2016-11-16

4. 张雨青、刘东,一种虎耳草猪肺混合水提物、其制备方法及应用,中国专利,CN105380967A 2015-11-27

5. 张雨青、刘华瑜,一种桑皮粉、制备方法及其应用,中国专利,CN105029431A2016--19

6. 张雨青、许冰清,一种用于降血糖的白背三七冻干粉、制备方法及其应用,中国专利,CN104887732A2015-5-19

7. 张雨青、朱琳,一种蚕蛹羧甲基壳聚糖、制备方法及其应用,中国专利,CN104817649A2015-5-12

8. 张雨青,伍敏晖,万良泽,一种N-脂肪酰基氨基酸钠表面活性剂及其制备方法,中国专利,201410089532.7, 2014-3-12

9. 曹婷婷、张雨青;一种折叠滤纸,实用新型专利,CN201420267420.1, 2014-5-23

10. 王海燕、张雨青;一种电聚丝素水凝胶膜的制备方法、装置及其应用,发明专利,CN201410221710.7,2014-5-23

11. 张雨青等,一种蚕丝脱胶/精练剂及其应用,发明专利,CN103205885A, 2013-7-17

12. 张雨青等,一种利用强碱性电解水低温缫丝的方法,发明专利,CN102605436A, 2012-7-25

13. 张雨青等,一种柱层析上样装置,发明专利,CN101923078A1, 2012-11-06

14. 张雨青等,一种桑树枝条剥皮机,发明专利,CN101811318 (A), 2010-08-25

15. 张雨青等,一种护肤用蚕丝扑粉的制备及使用方法,发明专利,CN101780024A, 2010-7-21

16. 张雨青等,一种从紫甘薯中提取花色苷的方法,发明专利,CN101735644A, 2010-6-16

17. 张雨青等,一种蚕茧丝胶层醇溶物及其制备方法,发明专利,200910027117.82011-4-13授权

18. 张雨青等,一种具有降血糖活性的桑皮提取物及其制备方法,发明专利,CN10133694A2009-1-7

19. Yu-Qing Zhang. A method of producing nanosize fibroin particle, PCT, WO 2005085327 A1, 2005. 9. 15.

 20. Yu-Qing Zhang. Silk fibroin nanoparticles fixed with enzyme and their production, PCT, WO2007112679A1, 2007.10.11.

成果/Honor Rewards

1. 2018年度  指导研究生《环保型蚕丝脱胶剂对丝素纤维性能的影响及其废液中丝胶回收》获得江苏省优秀硕士学位论文[苏学位字(2018)11]

2. 2013年度《丝胶回收与综合利用关键技术及产业化》获国家科技进步二等奖,排名第五(2013-J-212-2-03-R05)

3. 2012年度《荧光判性家蚕新品种的育成及雄蚕丝的开发》获教育部科学技术进步二等奖,排名第(1-2-9)

4. 2003年度《纳米丝素中SOD固定化研究及其纳米产品》获第八届挑战杯全国大学生课外学术科技作品竞赛二等奖,指导教师

5. 2002年度《利用Bm-NPV表达丙型肝炎病毒抗原蛋白》获苏州市科技进步二等奖,排名第五(No.2-22-5)

6. 2000年度《以固定化酶丝素膜为基础的葡萄糖尿酸生物传感器的研究》获江苏省科技进步三等奖,排名第一(No.3-51-1)

7. 1995年度《珍珠漂白工艺(中试)》获江苏省科技进步四等奖,排名第三(No.4-2 -3)

科研项目

1.“十三·五”国家现代农业产业技术体系《蚕丝资源综合利用》岗位,2016-2020,主持;

2.“十二·五”国家现代农业产业技术体系《茧丝深加工利用》岗位,2011-2015,主持;

3.“十一·国家现代农业产业技术体系《蚕茧深加工》岗位,2008-2010,主持;

4. 国家高技术研究发展计划(863)计划《家蚕基因表达谱和蛋白质组研究》(2006AA10A118), 2006-2010,任课题组副组长,主持课题五。




荣誉奖励
开授课程
招生信息
  • 1、

2020年招收

1. 生物物理学:硕士研究生

2. 畜牧学:硕士研究生

3. 畜牧学:博士研究生

在读研究生:

1. 特种经济动物饲养硕士在读生:荆凤雅、李际鑫

2. 特种经济动物饲养博士学位在读生:魏珍珍

已毕业的硕士研究生:

1. 生物物理:

  马永雷、周丽霞(2010);贺天珍、李琳、周珍祯(2011);刘先明、王元净、闫倩倩(2012);房蒙、马斌(2013);伍敏晖、赵丽君(2014);王姝、赵金鸽(2015);洪捷、刘华瑜、万良泽、余晓红(2016);刘东、吕毅、王飞、许冰清(2017);丁彪、王江(2018);殷晓路(2019);赵之林(2020);董璇、赵书祥(2021)

2. 特种经济动物饲养:

  陶美林(2003)、马燕(2004)、周文林(2004)、阎海波(2009)、王恒达(2022)、钟志豪(2022)、

3. 农业昆虫与害虫防治:

  相入丽(2008)

4. 动物学:

  卢立真(2010)

5. 农业推广:

  杨萍(2015)

已毕业的博士研究生:

1. 特种经济动物饲养:

  朱琳(2015)、王海燕(2016)、曹婷婷(2017)、郑丽屏(2018)、翁渝洁(2021)、张萌(2022)

2. 药物化学:

  赵金鸽(2018)、仇凡(2019)

合作的博士后:

1. 王海燕(2021)