个人信息
个人简介

胡广,博士,教授2005年和2010年分别于兰州大学获得化学学士和物理化学博士学位。20102011年在比利时鲁汶大学从事博士后研究。2012年入职苏州大学,期间于2014年到2015年在美国匹兹堡大学医学院从事访问研究。目前任中国细胞学会功能基因组信息学与系统生物学分会理事, 中国运筹协会计算系统生物学分会副秘书长,江苏省生物信息学专业委员会委员, SCI杂志 Current Bioinformatics 编委,中国循证医学杂志青年编委。




研究领域

生物信息学

医学系统生物学

基本信息
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胡广

职称:教授

院部/部门:苏州医学院基础医学与生物科学学院

学历:

学位:

毕业学校:

毕业专业:

联系方式

通讯地址:

邮政编码:

电子邮箱:huguang@suda.edu.cn

联系电话:0512-65221382

传真号码:

办公地点:苏州大学独墅湖校区403幢

科学研究

目前主要从事蛋白质结构及组学相关的网络分析,包括蛋白质结构网络、弹性网络模型、结构蛋白质相互作用网络三种不同层次的网络构建与分析。希望通过各个层次的蛋白相关网络分析,为在分子水平上理解复杂疾病发生机制、指导别构药物设计和蛋白质相互作用靶向药物设计提供理论指导。在理论化学,计算生物学和系统生物学等交叉学科SCI杂志上发表论文60余篇。先后主持包括国家自然科学基金面上项目,科技部中外合作项目共11项。

科研团队

20级:刘兴义

21级:周子筠

22级:杨彬


已毕业学生

18级:王帆, 杨季

19级:宋一丹

论文


主要作者文章: 51篇,2014年以后36篇,其中第一作者8篇,并列第一作者2篇,通讯作者15篇,并列通讯11篇。全部文章列表链接:https://www.webofscience.com/wos/author/record/B-2909-2012



2023 (6 PUBLICATIONS)


TRIM21 is a druggable target for the treatment of metastatic colorectal cancer through ubiquitination and activation of MST2

Yu-Yuan Liu, Shan Wan, Xiao-Qin Yang,Yi Wang, Wen-Juan Gan, Wen-Long Ye, Xiao-Shun He, Jun-Jie Chen, Yun Yang, Xue-Mei Yang, Xin Guo, Xiao-Jiao Gao, Yi-Tan Lu, Zhi-Yong Deng, Guang Hu, Hua Wu. Cell Chemical Biology 2023 (SCI大类一区,并列通讯作者


Functional insight into Cordyceps militaris sugar transporters by structure modeling, network analysis and allosteric regulation

Xin Liu, Hanyang Zhang, Ziyun Zhou, Pranesha Prabhakaran, Wanwipa Vongsangnak, Guang Hu, Fei Xiao. Physical Chemistry Chemical Physics 2023 (SCI大类二区,并列通讯作者)


Identifying Lymph Node Metastasis-Related Factors in Breast Cancer Using Differential Modular and Mutational Structural Analysis

Xingyi Liu , Bin Yang , Xinpeng Huang, Wenying Yan , Yujuan Zhang, Guang Hu. Interdisciplinary Sciences: Computational Life Sciences 2023 (SCI大类三区,通讯作者)中文报道


MiR-200/183 family-mediated module biomarker for gastric cancer progression: an AI-assisted bioinformatics method with experimental functional survey

Wenying Yan, Yuqi Chen, Guang Hu, Tongguo Shi, Xingyi Liu, Juntao Li, Linqing Sun, Fuliang Qian, Weichang Chen. Journal of Translational Medicine 2023 (SCI大类二区,并列第一作者)


HNRNPA2B1 as a potential therapeutic target for thymic epithelial tumor recurrence: An integrative network analysis

Ziyun Zhou, Yu Lu, Zhitao Gu, Qiangling Sun, Wentao Fang, Wei Yan, Xin Ku, Zhongjie Liang, Guang Hu. Computers in Biology and Medicine 2023 (SCI大类二区,通讯作者)


PPICT: an integrated deep neural network for predicting inter-protein PTM cross-talk

Fei Zhu, Lei Deng, Yuhao Dai, Guangyu Zhang, Fanwang Meng, Cheng Luo, Guang Hu, Zhongjie Liang. Briefings in Bioinformatics 2023(SCI大类二区,并列通讯作者)



2022 (4 PUBLICATIONS)


Leveraging Protein Dynamics to Identify Functional Phosphorylation Sites using Deep Learning Models

Fei Zhu, Sijie Yang, Fanwang Meng, Yuxiang Zheng, Xin Ku, Cheng Luo, Guang Hu, Zhongjie Liang. Journal of Chemical Information and Modeling 2022(SCI大类二区,并列通讯作者)


Dissecting mutational allosteric effects in alkaline phosphatases associated with different Hypophosphatasia phenotypes: An integrative computational investigation

Fei Xiao, Ziyun Zhou, Xingyu Song, Mi Gan, Jie Long, Gennady Verkhivker, Guang Hu, PloS Computational Biology 2022 (SCI大类二区,通讯作者)


Biophysical Insight into the SARS-CoV2 Spike-ACE2 Interaction and Its Modulation by Hepcidin through a Multifaceted Computational Approach

Hamid Hadi-Alijanvand, Luisa Di Paola, Guang Hu, David M Leitner, Gennady M Verkhivker, Peixin Sun, Humanath Poudel, Alessandro Giuliani. ACS Omega 2022 (SCI大类三区,并列通讯作者)


Structural Biology Meets Biomolecular Networks: The Post-AlphaFold Era

Wenying Yan, Guang Hu. Current Bioinformatics 2022 (SCI大类四区,通讯作者)



2021 (6 PUBLICATIONS)


Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family

Huimin Zhang, Jixiao He, Guang Hu, Fei Zhu, Hao Jiang, Jing Gao, Hu Zhou, Hua Lin, Yingjuan Wang, Kaixian Chen, Fanwang Meng, Minghong Hao, Kehao Zhao, Cheng Luo, Zhongjie Liang, Journal of Medicinal Chemistry 2021 (SCI大类二区,并列第一作者)


Insights into Conformational Dynamics and Allostery in DNMT1-H3Ub/USP7 Interactions

Yu Zhu, Fei Ye, Ziyun Zhou, Wanlin Liu, Zhongjie Liang, Guang Hu, Molecules 2021 (SCI大类三区,通讯作者)


Editorial: Understanding Protein Dynamics, Binding and Allostery for Drug Design

Guang Hu, Pemra Doruker, Hongchun Li, Ebru Demet Akten, Frontiers in Molecular Biosciences 2021 (SCI大类二区,第一作者)


Knowledge-Guided Community Network Analysis Reveals the Functional Modules and Candidate Targets in Non-Small-Cell Lung Cancer

Fan Wang , Shuqing Han, Ji Yang, Wenying Yan, Guang Hu, Cells 2021 (SCI大类二区,通讯作者)


Network-Based Target Prioritization and Drug Candidate Identification for Multiple Sclerosis: From Analyzing Omics Data to Druggability Simulations

Ji Yang, Hongchun Li, Fan Wang, Fei Xiao, Wenying Yan, Guang Hu, ACS Chemical Neuroscience 2021 (SCI大类二区,通讯作者)


Identification of Allosteric Effects in Proteins by Elastic Network Models

Guang Hu, Methods in Molecular Biology 2021 (唯一作者)



2020 (8 PUBLICATIONS)


The Discovery of a Putative Allosteric Site in the SARS-CoV-2 Spike Protein Using an Integrated Structural/Dynamic Approach

Luisa Di Paola, Hamid Hadi-Alijanvand, Xingyu Song, Guang Hu, Alessandro Giuliani, Journal of Proteome Research 2020 (SCI大类二区,并列通讯作者)


Comparative Dynamics and Functional Mechanisms of the CYP17A1 Tunnels Regulated by Ligand Binding

Fei Xiao, Xingyu Song, Peiyi Tian, Mi Gan, Gennady M Verkhivker, Guang Hu, Journal of Chemical Information and Modeling 2020(SCI大类二区,通讯作者) 中文报道


Identifying Drug Targets in Pancreatic Ductal Adenocarcinoma Through Machine Learning, Analyzing Biomolecular Networks, and Structural Modeling

Wenying Yan, Xingyi Liu, Yibo Wang, Shuqing Han, Fan Wang, Xin Liu, Fei Xiao, Guang Hu, Frontiers in Pharmacology 2020(SCI大类二区,通讯作者)


Both intra and inter-domain interactions define the intrinsic dynamics and allosteric mechanism in DNMT1s

Zhongjie Liang, Yu Zhu, Jie Long, Fei Ye, Guang Hu, Computational and Structural Biotechnology Journal 2020 (SCI大类二区,通讯作者)


Modulation of Toroidal Proteins Dynamics in Favor of Functional Mechanisms upon Ligand Binding

Hongchun Li, Pemra Doruker, Guang Hu, Ivet Bahar, Biophysical Journal 2020 (SCI大类三区,并列通讯作者)


Probing Carbon Utilization of Cordyceps militaris by Sugar Transportome and Protein Structural Analysis

Kanokwadee SirithepFei XiaoNachon RaethongYuhan ZhangKobkul LaotengGuang HuWanwipa Vongsangnak, Cells 2020 (SCI大类二区,并列通讯作者)


Integration of network models and evolutionary analysis into high-throughput modeling of protein dynamics and allosteric regulation: theory, tools and applications

Zhongjie Liang, Gennady M Verkhivker, Guang Hu, Briefings in Bioinformatics 2020 (SCI大类一区,通讯作者)


Role of protein-protein interactions in allosteric drug design for DNA methyltransferases

Zhongjie Liang, Yu Zhu, Xingyi Liu, Guang Hu, Advances in Protein Chemistry and Structural Biology 2020 (SCI大类三区,通讯作者)



2019 (1 PUBLICATION)


Modeling of PH Domains and Phosphoinositides Interactions and Beyond

Jiarong Feng, Lei He, Yuqian Li, Fei Xiao, Guang HuAdvances in Experimental Medicine and Biology 2019 (SCI大类三区,通讯作者)



2018 (2 PUBLICATIONS)


Recent Advances on the Network Models in Target-based Drug Discovery

Wenying Yan, Daqing Zhang, Chen Shen, Zhongjie Liang, Guang Hu, Current Topics in Medicinal Chemistry 2018 (SCI大类三区,通讯作者)


Deciphering the role of dimer interface in intrinsic dynamics and allosteric pathways underlying the functional transformation of DNMT3A

Zhongjie Liang, Junchi Hu, Wenying Yan, Hualiang Jiang, Guang Hu, Cheng Luo, Biochimica et Biophysica Acta (BBA) - General Subjects 2018(SCI大类二区,并列通讯作者)



2017 (4 PUBLICATIONS)


Protein-protein Interface and Disease: Perspective from Biomolecular Network

Guang Hu, Fei Xiao, Yuqian Li, Yuan Li, Wanwipa Vongsangnak, Advances in Biochemical Engineering/Biotechnology 2017 (SCI大类三区,第一作者)


Network Proteomics: From Protein Structure to Protein-Protein Interaction

Guang Hu, Luisa Di Paola, Filippo Pullara, Zhongjie Liang, Intawat Nookaew, BioMed Research International 2017 (SCI大类三区,第一作者)


Comparative Study of Elastic Network Model and Protein Contact Network for Protein Complexes: the Hemoglobin case

Guang Hu, Luisa Di Paola, Zhongjie Liang, Alessandro Giuliani, BioMed Research International 2017 (SCI大类三区,第一作者)


Intrinsic Dynamics Analysis of a DNA Octahedron by Elastic Network Model

Guang Hu, Lei He, Federico Iacovelli, Mattia Falconi, Molecules 2017 (SCI大类三区,第一作者)



2016 (2 PUBLICATIONS)


Protein Structure Network-based Drug Design

Zhongjie Liang, Guang Hu, Mini-Reviews in Medicinal Chemistry 2016 (SCI大类三区,通讯作者)


Network Analysis of Protein Structures: The Comparison of Three Topologies

Wenying Yan, Guang Hu, Bairong Shen, Current Bioinformatics 2016 (SCI大类四区,共同通讯作者)



2015 (1 PUBLICATION)


Computational Analysis of the Binding Specificities of PH Domains

Zhi Jiang, Zhongjie Liang, Bairong Shen, Guang Hu, BioMed Research International 2015 (SCI大类三区,第一作者)



2014 (2 PUBLICATIONS)


Molecular Design of DNA Polyhedra based on Genus

Jin-Wei Duan, Wei Li, Xiao-Wei Li, Guang Hu, Wen-Yuan Qiu, Journal of Mathematical Chemistry 2014 (SCI大类四区,并列通讯作者)


Residue interaction network analysis of Dronpa and a DNA clamp

Guang Hu, Wenying Yan, Jianhong Zhou, Bairong Shen,Journal of Theoretical Biology 2014 (SCI大类三区,第一作者)


荣誉奖励
  • 1、入选2012年苏州市科研院所紧缺高层次人才
  • 2、2017年 《生物信息学》优秀审稿专家
  • 3、2018年 Top Reviewers for Immunology
开授课程

蛋白质组信息学

科研论文写作

生物网络分析


招生信息

硕士生:医学系统生物学