报告题目：Structural Biological Studies of Energy and Nucleic Acid Metabolism
报告人简介：Dr. Song Xiang received his Bachelor's and master's degrees in physics from Fudan University and the City College of New York, City University, in 1997 and 1999, before switching fields to biology. In 2004 he received his PhD in Biophysics from the State University of New York at Stony Brook. He did his postdoctoral training at Columbia University, from 2004 to 2009. He joined the Institute of Nutritional Sciences in 2009.
Song Y#, Zhai L#, Chen Y, Valencia Swain J, Wang P, Chen L, Liu Y, Xiang S*, Structural Insights into the CRTC2-CREB Complex Assembly on CRE. Nucleic Acids Research (in revision)
Zhai L, Feng L, Xia L, Yin H, Xiang S*, Crystal Structure of Glycogen Debranching Enzyme and Insights into Its Catalysis and Disease-Causing Mutations. Nature Communications. 2016; 7:11229
报告题目：Involvement of miR-451 and glycerol kinase in glucose and lipid homeostasis and metabolic diseases
报告人： Yingying Le (乐颖影)
报告人简介： Laboratory of Nutrition and Inflammation Related Diseases，Institute for Nutritional Sciences SIBS, Chinese Academy of Sciences
1. Yao P, Zhuo S, Mei H, Chen X, Li N, Zhu T, Chen S, Wang JM, Hou R, Le Y*. Androgen alleviates neurotoxicity of b-amyloid peptide (Ab) by promoting microglial clearance of Ab and inhibiting microglial inflammatory response to Ab. CNS Neurosci Ther. 2017, in press
2. Mei H, Yao P, Wang S, Li N, Zhu T, Chen X, Yang M, Zhuo S, Chen S, Wang JM, Wang H, Xie D, Wu Y, Le Y*. Chronic low-dose cadmium exposure impairs cutaneous wound healing with defective early inflammatory responses after skin injury. Toxicol Sci. 2017 Jun 29. doi: 10.1093/toxsci/kfx137. [Epub ahead of print]
3. Xing HY, Li B, Peng D, Wang CY, Wang GY, Li P, Le YY, Wang JM, Ye G, Chen JH. A novel monoclonal antibody against the N-terminus of Aβ1-42 reduces plaques and improves cognition in a mouse model of Alzheimer's disease. PLoS One. 2017;12(6):e0180076.
4. Zhuo S, Yang M, Zhao Y, Chen X, Zhang F, Li N, Yao P, Zhu T, Mei H, Wang S, Li Y, Chen S, Le Y*. MicroRNA-451 Negatively Regulates Hepatic Glucose Production and Glucose Homeostasis by Targeting Glycerol Kinase-Mediated Gluconeogenesis. Diabetes. 2016;65(11):3276-3288.