姓  名:苏雄
技术职称:特聘教授
导师类型:博士生导师
所在学系:生物化学与分子生物学系
学科专业:生物化学与分子生物学
电子邮件:xsu@suda.edu.cn
研究方向

1、疾病中的脂代谢异常

2、少量脂肪酸(minor fatty acids)的代谢功能

个人简历

1998年获得北京大学理学学士学位。2004年获美国华盛顿大学 (St. Louis)博士学位。2004开始于该校医学院细胞生物学与生理学系从事博士后研究。2007年于该校医学院内科系人类营养学中心任研究助理教授,进行脂代谢研究。2010年任该中心助理教授 (Tenure Track) ,同时兼任细胞生物学与生理学系助理教授。从2012年10月开始受聘于苏州大学任特聘教授。  

学术成果

1.   Mitra MS, Chen Z, Ren H, Harris TE Harris TE, Brunt EM, Nadra K, Chrast, R, Su X, Morris AJ, and Finck BN (2012) Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal new roles for phosphatidic acid phosphatase activity in metabolic regulation. Proc Natl Acad Sci USA. accepted.

2.   Pietka TA, Sulkin MS, Kuda O, Wang W, Zhou D, Yamada KA, Yang K, Su X, Gross RW, Nerbonne JM, Efimov IR, and Abumrad NA (2012) CD36 influences myocardial Ca2+ homeostasis and phospholipid metabolism: Conduction anomalies in CD36 deficient mice during fasting. J Biol Chem 287(46):38901-12

3.   Bradley D, Conte C, Mittendorfer B, Eagon JC, Varela JE, Fabbrini E, Gastaldelli A, Chambers KT, Su X, Okunade A, Patterson BW, Klein S (2012) Effects of gastric bypass and adjustable gastric banding on glucose homeostasis. J Clin Invest, in press, PMID: 23187122.

4.   Kong C, Samovski D, Srikanth P,  Wainszelbaum MJ, Audra J. Charron AJ, Jialiu Liu J, Jeffrey J. Lange JJ, Chen PI, Pan ZQ, Su X* and Stahl PD* (2012) Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is mediated by CUL7 E3 ligase. PLoS ONE, 7(9): e46485.

5.   Zhou D, Samovski D, Okunade AL, Stahl PD, Abumrad NA, and Su X* (2012) CD36 level and trafficking are determinants of adrenergic stimulated lipolysis in adipocytes. FASEB J. 26(11):4733-42. PMID: 22815385

6.   Guo L, Zhang X, Zhou D, Okunade AL, and Su X* (2012) Stereospecificity of Fatty Acid 2-Hydroxylase and Differential Biological Regulations by 2-Hydroxy Fatty Acid Enantiomers.  J Lipid Res, 53(7): 1327–1335. PMCID: PMC3371244

7.   Magkos F1, Su X1, Bradley D, Fabbrini E, Conte C, Eagon JC, Varela E, Brunt E, Patterson BW, and Klein S (2012) Intrahepatic diacylglycerol content is directly associated with hepatic insulin resistance in obese subjects. Gastroenterology, 142(7): 1444-1446. (1 equal contribution).

8. Samovski D, Su X, Xu Y, Abumrad NA, and Stahl PD (2012) Insulin and AMPK regulate fatty acid translocase/CD36 plasma membrane recruitment in cardiomyocytes via RabGAP AS160 and Rab8a Rab GTPase. J Lipid Res, 53(4):709-17. PMCID: PMC3307647

9.   Wainszelbaum MJ, Liu J, Kong C, Srikanth P, Samovski D, Su X*, and Stahl PD* (2012) TBC1D3, a Hominoid-specific Gene, Delays IRS-1 Degradation and Promotes Insulin Signaling by Modulating p70 S6 Kinase Activity. PLoS ONE, 7(2):e31225. PMCID: PMC3278430

10. Kuda O, Jenkins CM, Skinner JR, Moon SH, Su X, Gross RW, and Abumrad NA (2011) CD36 Protein Is Involved in Store-operated Calcium Flux, Phospholipase A2 Activation, and Production of Prostaglandin E2. J Biol Chem, 286(20):17785-95. PMCID: PMC3093854

11. Mitra MS, Schilling JD, Wang X, Jay PY, Huss JM, Su X, and Finck BN (2011) Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor γ coactivator 1α/estrogen related receptor axis. J Mol Cell Cardiol, 51, 120-8. PMCID: PMC3104300

12. Fabbrini E, Magkos F, Su X, Abumrad NA, Nejedly N, Coughlin CC, Okunade AL, Patterson BW, and Klein S (2011) Insulin sensitivity is not associated with palmitoleate availability in obese humans. J Lipid Res, 52, 808-12. PMCID: PMC3053209

13. Mancuso DJ, Sims HF, Yang K, Kiebish MA, Su X, Jenkins CM, Guan S, Moon SH, Pietka T, Nassir F, Schappe T, Moore K, Han X, Abumrad NA, and Gross RW (2010) Genetic Ablation of Calcium-independent Phospholipase A2γ Prevents Obesity and Insulin Resistance during High Fat Feeding by Mitochondrial Uncoupling and Increased Adipocyte Fatty Acid Oxidation. J Biol Chem, 285, 36495-510. PMCID: PMC2978578

14. Guo L, Zhou D, Pryse KM, Okunade AL, and Su X* (2010) Fatty Acid 2-Hydroxylase Mediates Diffusional Mobility of Raft-associated Lipids, GLUT4 Level and Lipogenesis in 3T3-L1 Adipocytes. J Biol Chem, 285, 25438-47. PMCID: PMC20519515

15. Liu Y, Zhou D, Abumrad NA, and Su X* (2010) ADP-Ribosylation Factor 6 Modulates Adrenergic Stimulated Lipolysis in Adipocytes. Am J Physiol-Cell Physiol, 298, C921–C928. PMCID: PMC2853220

16. Meng C, Su X, Yang J, Jenkins CM, Cedars A, and Gross RW (2010) Facile Identification and Quantitation of Protein Phosphorylation via b-Elimination and Michael Addition with Natural Abundance and Stable Isotope Labeled Thiocholine. Anal Chem, 82, 163-71. PMCID: PMC2813211

17. Su X, and Abumrad NA (2009) Cellular fatty acid uptake: a pathway under construction. Trends Endocrinol Metab 20, 72-77. PMCID: PMC2845711

18. Chen PI, Kong C, Su X, and Stahl PD (2009) Rab5 Isoforms Differentially Regulate the Trafficking and Degradation of Epidermal Growth Factor Receptors. J Biol Chem, 284, 30328-30338. PMCID: PMC2781588

19. Smith J1, Su X1, El-Maghrabi R, Stahl PD, and Abumrad NA (2008) Opposite Regulation of CD36 Ubiquitination by Fatty Acids and Insulin. J Biol Chem 283, 13578-85. PMCID: PMC2376227 (1 equal contribution)

20. Su X, Kong C, and Stahl PD (2007) GAPex-5 Mediates Epidermal Growth Factor Receptor Ubiquitination, Trafficking and Degradation. J Biol Chem 282, 21278-84. PMID: 17545148

21. Kong C, Su X, Chen PI, and Stahl PD (2007) Rin1 Interacts with Signal-transducing Adaptor Molecule (STAM) and Mediates Epidermal Growth Factor Receptor Trafficking and Degradation. J Biol Chem. 282,15294-301. PMID: 17403676

22. Li YL, Su X, Stahl PD, and Gross ML (2007) Quantification of diacylglycerol molecular species in biological samples by electrospray ionization mass spectrometry after one-step derivatization.  Anal Chem 79, 1569-74. PMID: 17297957

23. Hodzic D, Kong C, Wainszelbaum MJ, Charron AJ, Su X, and Stahl PD (2006) TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.  Genomics 88, 731-736. PMID: 16863688

24. Su X, Lodhi IJ, Saltiel AR, and Stahl PD (2006) Insulin-stimulated Interaction between Insulin Receptor Substrate 1 and p85α and Activation of Protein Kinase B/Akt Require Rab5.  J Biol Chem 281:27982-27990. PMID: 16880210

25.       Su X, Han X, Mancuso DJ, Abendschein DR, and Gross RW (2005) Accumulation of Long Chain Acylcarnitine and β-Hydroxy Acylcarnitine Molecular Species in Diabetic Myocardium: Identification of Alterations in Mitochondrial Fatty Acid Processing in Diabetic Myocardium by Shotgun Lipidomics. Biochemistry 44: 5234-5245. PMID: 15794660

26.       Su X, Han X, Yang J, Mancuso DJ, Chen J, Bickel PE, and Gross RW (2004) Sequential Ordered Fatty Acid a Oxidation and ∆9 Desaturation Are Major Determinants of Lipid Storage and Utilization in Differentiating Adipocytes. Biochemistry 43: 5033-5044. PMID: 15109262

27.       Su X, Mancuso DJ, Bickel PE, Jenkins CM, and Gross RW (2004) Small Interfering RNA Knockdown of Calcium-independent Phospholipases A2β or γ Inhibits the Hormone-induced Differentiation of 3T3-L1 preadipocytes. J Biol Chem 279: 21740-21748. PMID: 15024020

* 通讯作者

代表项目

835140N, Su (PI)                                          07/01/2008 – 06/30/2012               

AHA – National Center, Scientist Development Grant                     

 CD36 Ubiquitination and Lipid Metabolism

R21 DK082951, Su (PI)                                 03/01/2009 – 02/28/2011                

NIH/NIDDK                                 

  Fatty Acid α Oxidation in Adipocytes


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