姓  名:周翊峰
技术职称:教授
导师类型:硕导
所在学系:遗传学
学科专业:遗传学
电子邮件:zhouyifeng@suda.edu.cn
研究方向

肿瘤遗传学

肿瘤病因学

个人简历
2005年毕业于北京协和医科大学/中国医学科学院,获得博士学位。2005-2008年期间在美国华盛顿大学(University of Washington)从事肿瘤免疫学方面的博士后研究。2008年9月,作为引进人才,经招聘到苏州大学工作,并被聘为教授。近年来,已在国内外专业杂志发表论文40余篇,其中SCI杂志37篇。总I.F.超过260,总引用次数531次,其中他引473次(引证文献作者不包括被引文献的任意作者);第一和通讯作者18篇(总I.F.超过80):包括“Journal of Experimental Medicine” (I.F. 14.48) 、“Cancer Research”(2篇,I.F. 8.23)、“Carcinogenesis”(3篇,I.F. 5.70)、“International Journal of Cancer”(I.F. 5.44) 、“Breast Cancer Research and Treatment” (I.F. 4.86) 和“Cancer Science” (I.F. 3.85)等;个人H因子14(H-index)。并以第一发明人申请国家发明专利四项,授权专利一项。
学术成果

1.Zheng J, Liu B, Zhang L, Jiang L, Huang B, You Y, Jiang Q, Zhang S, Lu J*, Zhou Y*. The protective role of polymorphism MKK4 -1304 T>G in nasopharyngeal carcinoma is modulated by Epstein-Barr virus’ infection status. Int J Cancer. 2012 130: 1981-1990.(*通讯作者 IF=5.44)

2.Hu M, Jian L, Zhang L, Zheng J, You Y, Deng J, Li H, Zhou Y*. Functional polymorphism in the EpCAM gene is associated with occurrence and advanced disease status of cervical cancer in Chinese population. Mol Biol Rep. 2012 39: 7303-7309.(*通讯作者IF=2.90)

3.Jiang L, Zhou P, Sun A, Zheng J, Liu B, You Y, Zhang C, Wu D, Zhou Y*. Functional variant (-1304T>G) in the MKK4 promoter is associated with decreased risk of acute myeloid leukemia in a southern Chinese population. Cancer Sci. 2011 102:1462-1468.(*通讯作者IF=3.85)

4.Jiang L, Zhang C, Li Y, Yu X, Zheng J, Zou P, Li Y, Bin X, Lu J*, Zhou Y*. A non-synonymous polymorphism Thr115Met in the EpCAM gene is associated with an increased risk of breast cancer in Chinese population. Breast Cancer Res Treat. 2011 126:487-495.(*通讯作者IF=4.86)

5.Zheng J, Zhang C, Jiang L, You Y, Liu Y, Lu J, Zhou Y*. Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma. Mol Carcinog. 2011 50:689-696.(*通讯作者IF=3.27)

6.Zheng J, Chen S, Jiang L, You Y, Wu D*, Zhou Y*. Functional Genetic Variations of Cyclooxygenase-2 and Susceptibility to Acute Myeloid Leukemia in a Chinese Population. Eur J Haematol. 2011 87:486-493.(*通讯作者IF=2.79)

7.Xu J, He X, Jin L, Jiang L, Zhou Y*, Kang Z*, Peng R*, Lee ST. A protein-based electrochemical method for label-free characterization of sequence-specific protein-DNA interactions. Electrochim Acta. 2011 56:5759-5765.(*通讯作者IF=3.64)

8.Hu Y, Jiang L, Zheng J, You Y, Zhou Y*, Jiao S*. Association between the P73 exon2 G4C14-to-A4T14 polymorphism and cancer risk: a meta-analysis. DNA and Cell Biology. 2012 31: 230-237.(*通讯作者IF=2.16)

9.Wang Y, Zheng J, Liu P, Yu X, Zhou D*, Jiang L, You Y, Zhou Y*. Association between the Interleukin 10 -1082G>A polymorphism and coronary heart disease risk in a Caucasian population: a meta-analysis. Int J Immunogenet. 2012 Accepted.(*通讯作者IF=1.62)

10.Yu X, Zhang C, Sun A, Jiang L, Zheng J, You Y, Wu D*, Zhou Y*. Genetic variations in CD14 promoter and acute lymphoblastic leukemia susceptibility in a Chinese population. DNA and Cell Biology. 2011 30:777-782.(*通讯作者IF=2.16)

11.Jiang L, Liang J, Jiang M, Yu X, Zheng J, Liu H, Wu D*, Zhou Y*. Functional polymorphisms in the NBS1 gene and acute lymphoblastic leukemia susceptibility in a Chinese population. Eur J Haematol. 2011 86:199-205.(*通讯作者 IF=2.79)

12.Zheng J, Yu X, Jiang L, Xiao M, Bai B, Lu J, Zhou Y*. Association between the Cytotoxic T-Lymphocyte Antigen 4 +49G>A polymorphism and cancer risk: a meta-analysis. BMC Cancer. 2010 10:522.(*通讯作者IF=3.15)

13.Gao Y, He Y, Ding J, Wu K, Hu B, Liu Y, Wu Y, Guo B, Shen Y, Landi D, Landi S, Zhou Y*, Liu H*. An insertion/deletion polymorphism at miRNA-122 binding site in the interleukin- 1a 3’ untranslated region confers risk for hepatocellular carcinoma. Carcinogenesis. 2009 30:2064-2069.(*通讯作者IF=5.70)

14.Sun T, Zhou Y*, Yang M, Hu Z, Tan W, Han X, Shi Y, Yao J, Guo Y, Yu D, Tian T, Zhou X, Shen H, Lin D. Functional genetic variations in CTLA-4 and susceptibility to multiple types of cancer. Cancer Res. 2008 68:7025-7034.(*共同第一作者IF=8.23)

15.Sun T, Zhou Y*, Li H, Han X, Shi Y, Wang L, Miao X, Tan W, Zhao D, Zhang X, Guo Y, Lin D. FASL -844C polymorphism is associated with increased activation-induced T cell death and risk of cervical cancer. J Exp Med. 2005 202:967-974.(*共同第一作者IF=14.77)

16.Zhou Y, Yu C, Miao X, Wang Y, Tan W, Sun T, Zhang X, Xiong P, Lin D. Functional haplotypes in the promoter of matrix metalloproteinase-2 and lung cancer susceptibility. Carcinogenesis. 2005 26:1117-1121. (IF=5.70)

17.Yu C, Zhou Y*, Miao X, Xiong P, Tan W, Lin D. Functional haplotypes in the promoter of matrix metalloproteinase-2 predict risk of the occurrence and metastasis of esophageal cancer. Cancer Res. 2004 64:7622-7628.(*共同第一作者IF=8.23)

18.Zhou Y, Yu C, Miao X, Tan W, Liang G, Xiong P, Sun T, Lin D. Substantial reduction in risk of breast cancer associated with genetic polymorphisms in the promoters of the matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes. Carcinogenesis. 2004 25:399-404. (IF=5.70)

19.Yang M, Sun T, Zhou Y, Wang L, Liu L, Zhang X, Tang X, Zhou M, Kuang P, Tan W, Li H, Yuan Q, Yu D. The functional cytotoxic T lymphocyte-associated Protein 4 49G-to-A genetic variant and risk of pancreatic cancer. Cancer. 2012 Feb 22. [Epub ahead of print] (IF=5.10)

20.Huang D, Qiu F, Yang L, Li Y, Cheng M, Wang H, Ma G, Wang Y, Hu M, Ji W, Zhou Y, Lu J. The polymorphisms and haplotypes of WWOX gene are associated with the risk of lung cancer in southern and eastern Chinese populations. Mol Carcinog. 2012 Jun 12. [Epub ahead of print] (IF=3.27)

21.Huang B, Liu B, Yang L, Li Y, Cheng M, Huang D, Wang H, Zhang X, Zheng J, Li Q, Ji W, Zhou Y, Lu J. Functional genetic variants of c-Jun and their interaction with smoking and drinking increase the susceptibility to lung cancer in southern and eastern chinese. Int J Cancer. 2011131: E744-758. (IF=5.44)

22.Wu C, Miao X, Huang L, Che X, Jiang G, Yu D, Yang X, Cao G, Hu Z, Zhou Y, Zuo C, Wang C, Zhang X, Zhou Y, Yu X, Dai W, Li Z, Shen H, Liu L, Chen Y, Zhang S, Wang X, Zhai K, Chang J, Liu Y, Sun M, Cao W, Gao J, Ma Y, Zheng X, Cheung ST, Jia Y, Xu J, Tan W, Zhao P, Wu T, Wang C, Lin D. Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations. Nat Genet. 2011 44: 62-66. (IF=36.37)

23.Yang L, Li Y, Cheng M, Huang D, Zheng J, Liu B, Ling X, Li Q, Zhang X, Ji W, Zhou Y, Lu J. A functional polymorphism at microRNA-629 binding site in the 3'-untranslated region of NBS1 gene confers an increased risk of lung cancer in Southern and Eastern Chinese population. Carcinogenesis. 2012 33: 338-347. (IF=5.70)

24.Shi Y, Hu Z, Wu C, Dai J, Li H, Dong J, Wang M, Miao X, Zhou Y, Lu F, Zhang H, Hu L, Jiang Y, Li Z, Chu M, Ma H, Chen J, Jin G, Tan W, Wu T, Zhang Z, Lin D, Shen H. A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. Nat Genet. 201143: 1215-1218. (IF=36.37)

25.Lu J, Yang L, Zhao H, Liu B, Li Y, Wu H, Li Q, Zeng B, Wang Y, Ji W, Zhou Y. The polymorphism and haplotypes of PIN1 gene are associated with the risk of lung cancer in Southern and Eastern Chinese populations. Hum Mutat. 2011 32:1299-1308. (IF=5.96)

26.Wu C, Hu Z, He Z, Jia W, Wang F, Zhou Y, Liu Z, Zhan Q, Liu Y, Yu D, Zhai K, Chang J, Qiao Y, Jin G, Liu Z, Shen Y, Guo C, Fu J, Miao X, Tan W, Shen H, Ke Y, Zeng Y, Wu T, Lin D. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. Nat Genet. 2011 43:679-684. (IF=36.37)

27.Ding J, Gao Y, He Y, Zhou Y, Huang M, Liu H. Screening SNPs residing in the microRNA-binding sites of hepatocellular carcinoma related genes. Int J Data Min Bioinform. 2011 5:1-21. (IF=0.68)

28.Lin D, Liu C, Xue M, Liu R, Jiang L, Yu X, Bao G, Deng F, Yu M, Ao J, Zhou Y, Wu D, Liu H. The role of interleukin-15 polymorphisms in adult acute lymphoblastic leukemia. PLoS One. 2010 5:e13626. (IF=4.41)

29.Liu P, Jaffar J, Zhou Y, Yang Y, Hellström I, Hellström KE. Inhibition of TGFbeta1 Makes Nonimmunogenic Tumor Cells Effective for Therapeutic Vaccination. J Immunother. 2009 32:232-239. (IF=3.59)

30.Zhang B, Sun T, Xue L, Han X, Zhang B, Lu N, Shi Y, Tan W, Zhou Y, Zhao D, Zhang X, Guo Y, Lin D. Functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer. Carcinogenesis. 2007 28:1067-1073. (IF=5.70)

31.Yang Y, Yang S, Ye Z, Jaffar J, Zhou Y, Cutter E, Lieber A, Hellström I, Hellström KE. Tumor cells expressing anti-CD137 scFv induce a tumor-destructive environment. Cancer Res. 2007 67:2339-2344. (IF=8.23)

32.Hao B, Miao X, Li Y, Zhang X, Sun T, Liang G, Zhao Y, Zhou Y, Wang H, Chen X, Zhang L, Tan W, Wei Q, Lin D, He F. A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer. Oncogene. 2006 25:3613-3620. (IF=7.41)

33.Zhang X, Miao X, Guo Y, Tan W, Zhou Y, Sun T, Wang Y, Lin D. Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer. Hum Mutat. 2006 27:110-117. (IF=5.96)

34.Zhang X, Miao X, Sun T, Tan W, Qu S, Xiong P, Zhou Y, Lin D. Functional polymorphisms in cell death pathway genes FAS and FASL contribute to risk of lung cancer. J Med Genet. 2005 42:479-484. (IF=7.03)

35.Tan W, Miao X, Wang L, Yu C, Xiong P, Liang G, Sun T, Zhou Y, Zhang X, Li H, Lin D. Significant increase in risk of gastroesophageal cancer is associated with interaction between promoter polymorphisms in thymidylate synthase and serum folate status. Carcinogenesis. 2005 26:1430-1435. (IF=5.70)

36.Sun T, Miao X, Wang J, Tan W, Zhou Y, Yu C, Lin D. Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma. Carcinogenesis. 2004 25:2225-2230. (IF=5.70)

37.Liang G, Miao X, Zhou Y, Tan W, Lin D. A functional polymorphism in the SULT1A1 gene (G638A) is associated with risk of lung cancer in relation to tobacco smoking. Carcinogenesis. 2004 25:773-778. (IF=5.70)
代表项目

1.国家自然科学基金(No.81171895)“X染色体失活中心区域内遗传变异与乳腺癌发生发展关联研究”2012.01-2015.12; 主持人

2.国家自然科学基金(No.81001278)“11p13拷贝数多态与正常核型急性髓系白血病发生发展的关联研究”2011.01-2013.12;主持人

3.江苏省自然科学基金(No. BK2011297)“Xq13染色体区域内遗传变异与宫颈癌发生发展的关联研究”2011.07-2014.06;主持人

4.江苏省六大人才高峰(第八批);3万 在研;主持人

5.教育部归国留学人员科研启动基金(No.20101561)“CD25基因遗传变异与乳腺癌的相关性研究”2011.05-2012.04;主持人

6.华南肿瘤学国家重点实验室开放课题“CD226基因3’UTR区域microRNA结合位点内遗传多态与乳腺癌的相关性研究” 2010.05-2012.04;主持人

7.呼吸疾病国家重点实验室开放课题“FOXP3基因遗传变异与女性肺腺癌发生发展的关联研究”2012.01-2013.12;主持人
社会兼职

1.中国抗癌协会肿瘤病因学会专业委员会委员

2.中华预防医学杂志通讯编委

3.Breast Cancer Research and Treatment杂志审稿人

4.European Journal of Cancer杂志审稿人

5.Molecular Carcinogenesis杂志审稿人

6.DNA and Cell Biology杂志审稿人

7.Cancer Epidemiology杂志审稿人

8.Tumor Biology杂志审稿人

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