姓  名:韩宏岩
技术职称:副教授
导师类型:博导
所在学系:基础医学与生物科学学院
学科专业:生物化学与分子生物学系
电子邮件:hhy2469@126.com
研究方向

蛋白质结构与功能关系  

丝素蛋白构象调控与功能关系  

生物制药

个人简历

(1) 2014.7-至今, 苏州大学, 基础医学与生物科学院, 教授,博士生导师

(2) 2013.4-2014.6, The Scripps Research Institute.USA, Cancer Biology,Young Excellent Teacher Visiting Scholar.

(3) 2006.12-2013.3, 苏州大学, 基础医学与生物科学院, 副教授,硕士生导师

(4) 2004.7-2005.12, 清华大学, 生命科学学院, 访问学者

(5) 2003.6-2004.6, The University of Newcastle, Australia, Department of  Biomedical Sciences,  Visiting Scholar.

(6) 1990.9-2003.5, 山东农业大学, 生命科学院, 副教授

(7) 1988.9-1990.7, 武汉大学, 化学系, 讲师

(8) 1986.7-1988.8, 山东农业大学, 生命科学院, 助教

(9)山东师范大学,学士;山东农业大学,硕士;苏州大学,博士  

学术成果

1. Hongyan Han,Longsheng Dua , Zhifei Caoa,Bin Zhanga,Quansheng Zhou.Triptonide potently suppresses pancreatic cancer cell-mediated vasculogenic mimicry by inhibiting expression of VE-cadherin and chemokine ligand 2 genes.European Journal of Pharmacology, 2018.1, 818: 593~603

2. Bin Zhang  ,Hongyan Han∗, Quansheng Zhou,Shilong Fu,Ping Yang,Zhenlun Gu, Zhifei Cao, Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. Biochemical Pharmacology, 2016.3.15, 104:8~18

3.Han H , Ning H , Liu S , Lu Q , Fan Z , Lu H , Lu G , Kaplan DL . Silk Biomaterials with Vascularization Capacity. Advanced Functional Materials, 2016 Jan;26 (3): 421-436

4.H Han, S Bai,X Huang,W Xu, DL Kaplan , Lu Q. Silk scaffolds with tunable mechanical capability for cell differentiation. Acta Biomaterialia .2015,20(1):22-31

5.. Yue-Xiu Si , Sunyoung Ji , Wei Wanga, Nai-Yun Fanga, Qing-Xin Jin , Yong-Doo Parkd,Guo-Ying Qian, Jinhyuk Leeb, Hong-Yan Han∗,Shang-Jun Yin; Effects of boldine on tyrosinase: Inhibition kinetics and computational simulation; Process Biochemistry; 2013;48;152–161

6.. Chao Li , Yu-hua Chen, Zhen-wang Zhang, Cheng-liang Gong,Hong-yan Han∗, Wei-an Xu; Glu434 is an important amino acid residue for the activity, structure and stability of tyrosine hydroxylase of the silkworm, Bombyx mori; Process Biochemistry; 2013; 48 ;1665–1673

7. Chao-Jun Pei, Jinhyuk Lee, Yue-Xiu Si , Sangho Oh, Wei-An Xu, Shang-Jun Yin, Guo-Ying Qian,∗, Hong-Yan Han∗; Inhibition of tyrosinase by gastrodin: An integrated kinetic-computational simulation analysis; Process Biochemistry ;2013;48; 162–168

8. Xiao-Xia Liu , Shi-Qing Sun ,Yu-Jie Wang, Wei Xu, Yi-Fang Wang , Daeui Park, Hai-Meng Zhou ,

Hong-Yan Han∗. Kinetics and Computational Docking Studies on the Inhibition of Tyrosinase Induced by Oxymatrine; Appl Biochem Biotechnol;2013; 169;145–158

9. S. Bai, S. Liu, C. Zhang, W. Xub, Q. Lu, H. Han∗, D.L Kaplan c, H. Zhu; Controllable transition of silk fibroin nanostructures: An insight into in vitro silk self-assembly process; Acta Biomaterialia  2013;9; 7806–7813

10. Hong-Yan Han , He-Chang Zou, Jun-Yeong Jeon, Ye-Jing Wang,Wei-An Xu, Jun-Mo Yang , Yong-Doo Park; The inhibition kinetics and thermodynamic changes of tyrosinase via the zinc ion; Biochimica et Biophysica Acta; 2007;1774; 822–827

11. Hong-Yan Han, Jae-Rin Lee, Wei-An Xu, Myong-Joon Hah, Jun-Mo Yang, Yong-Doo Park; Effect of Cl- on Tyrosinase: Complex Inhibition Kinetics and Biochemical Implication; Journal of Biomolecular Structure & Dynamics; 2007; 25;2,165-171

12. Hong-Yan Han,Wei-An Xu,Zhi-Rong Lü,Fei Zou,Sen Li; Activation and Inactivation of orseradish Peroxidase by Cobalt Ions; Journal of Biomolecular Structure & Dynamics;2008;26;1;83-91

13. Hong-Yan Han,Zhi-Gang Yao,Cheng-Liang Gong,Wei-An Xu;The Protective Effects of Osmolytes On Yeast Alcohol Dehydrogenase Comformational Stability And Aggregation; protein & peptide letter;2010;17;1058-1066

14.Wei-An Xu,Hong-Yan Han∗;A Survey Of The Genera Of Microgaster Latreille And Hygroplitis And Hygroplitis Thomson(Hymenoptera:Braconidae:Microgastrinae) From China; Phytoparasitica; 2007; 35;1;86-99  

代表项目

1. 广西复鑫益创新团队研发项目,水蛭养殖和活性成分的产业化研究。

2. 国家自然科学基金面上项目(81572257),癌睾抗原CT45A1促进肺癌细胞侵袭和转移的作用及其机制。

 

其  他

苏州市自然科学优秀论文一等奖

山东农业大学第二届优秀教学质量二等奖

山东农业大学教学成果奖一等奖

教学改革的研究与实践获山东省省级教学成果奖


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