姓  名:洪法水
技术职称:教授
导师类型:博导
所在学系:医学部
学科专业:医学生物化学
电子邮件:Hongfsh_cn@sina.com
研究方向

1.免疫毒理分子机制

2.神经毒理分子机制

3.生殖毒理分子机制

个人简历
洪法水教授,博士,全国优秀教师, 博士生导师,目前主要从事纳米和稀土神经毒理、免疫毒理和生殖毒理分子机制的研究工作。1984年本科毕业于安徽大学生物系,2000年6月博士毕业于中国科技大学化学系分析化学专业。近些年完成国家级项目多项。
学术成果

1999年以来,已在国内外SCI刊源上发表论文144篇。

近五年发表的主要SCI论文有(通讯联系人):

1.Pulmotoxicological effects in mice caused by long term titanium dioxide  nanoparticules exposure. J Hazard Mater, doi.org/10.1016/j.jhazmat. 2012. 05.072, 2012 in press. (IF=4.173, SSCI一区)

2. Gene expression in liver injury caused by long-term exposure to titanium dioxide nanoparticles in mice. Toxicoll Sci, 10.1093/toxsci/KFS153, 2012 in press. (IF= 4.652 SCI 二区)

3.Titanium dioxide nanoparticles relieve biochemical dysfunctions of fifth-instar larvae of silkworm following exposure to phoxim insecticide. Chemosphere, doi.org/10.1016/j.chemosphere.2012.05.061, 2012 in press(IF=3.206, SCI 二区)

4. Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles. J Hazard Mater, 2011,191:32-40. (IF=4.173, SSCI一区)

6.Molecular mechanism of kidney injury of mice caused by exposure to titanium dioxide nanoparticles. J Hazard Mater, 2011,195:365-370 (IF=4.173, SSCI一区)

7.Splenocyte apopotic pathway in mice following exposure to cerium chloride. Chemosphere, 2011,8:612–617 IF=3.206, SCI 二区)

8. Oxidative stress in the brain of mice caused by translocated nanoparticulate TiO2 delivered to the abdominal cavity. Biomaterials, 2010, 31: 99-105.(IF=7.404, SCI一区)

9. Toxicological characteristics of nanoparticulate anatase titanium dioxide in mice. Biomaterials, 2010, 31: 894-899.(IF=7.404 SCI一区)

10.Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles. Biomaterials, 2010, 31: 8043-8050.(IF=7.404, SCI一区)

11.Hepatocyte apoptosis and its molecular mechanisms in mice caused by nanoparticulate anatase titanium dioxide. J Hazard Mater, 2010, 183: 874-880. (IF=4.173, SSCI一区)

12.Spleen injury and apoptotic pathway in mice caused by titanium dioxide nanoparticules. Toxicol Lett, 2010, 195: 161–168.(IF=3.23, SCI 二区)

13. Direct Evidence for Interaction between Lead Ions and Kidney DNA from Silver Crucian Carp. Chemosphere, 2007, 69: 1442-1446(IF=3.206, SCI 二区)

获奖情况:

曾获省科技进步奖两项。自从2002年招收研究生以来,所指导的硕士毕业研究生连续四年(2005-2011)被评为苏州大学优秀硕士学位论文,其中四篇被评为江苏省优秀硕士学位论文,三名硕士研究生获苏州大学生命科学英才奖(科研成果)三等奖。

代表项目
目前所领衔实验室承担国家自然科学基金资助项目“纳米氧化钛引起小鼠肝功能破坏的分子机制”(30901218)。参加(第二主持)国家自然科学基金重点项目“斑马鱼胚胎生物钟分子遗传和基因组机制的研究”(31030062)和国家重点基础研究发展计划(973计划)“重要纳米材料的生物效应机制与安全性评价研究”项目子课题“纳米颗粒安全性高通量筛选方法、评价方法与评价程序研究”(2011CB933404)。

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地址:苏州工业园区仁爱路199号 邮编:215123 电话:65880103 院长信箱:jcsw@suda.edu.cn