姓  名:王明华
技术职称:副教授
导师类型:硕导
所在学系:生物化学与分子生物学系
学科专业:生物化学与分子生物学
电子邮件:mhwang@suda.edu.cn
研究方向

1.  基因表达与调控

2.  肿瘤分子遗传学

个人简历

1995.7大学毕业于西北大学生物系生物学专业,毕业后于陕西省教育学院生化系任教。

1997.9-2000.1于西北农林科技大学基础科学系攻读生物化学与分子生物学专业硕士学位,并获理学硕士。硕士学位论文工作在中国科学院北京微生物研究所遗传室完成。毕业后在上海第二医科大学上海市发育生物学重点实验室进修半年。

2001.9-2005.1于复旦大学遗传所攻读遗传学专业博士学位,并获理学博士。在遗传工程国家重点实验室从事博士学位论文工作。

2005.5月至今在苏州大学基础医学与生物科学学院生物化学与分子生物系从事教学科研工作。2007年被聘为副教授。

2010.3-2012.2在美国约翰霍普金斯大学医学院高级访问研究。  
学术成果

1.Pu WL, Wang CJ, Chen SD, Zhao DM, Zhou YH, Ma YJ, Wang Y, Li CH, Huang ZB, Jin L, Guo SC, Wang JC, Wang MH. Targeted bisulfite sequencing identified a panel of DNA methylation-based biomarkers for esophageal squamous cell carcinoma (ESCC). Clinical Epigenetics. 2017 Dec 15;9:129 eCollection. (Corresponding author)

2.Fan LX, Chen LQ, Ni XL, Guo SC, Zhou YH, Wang CJ, Zheng YB, Shen FY, Kolluri V K, Muktiali M, Zhao ZH,Wu JJ, Zhao DM., He ZL., Feng XL, Yuan ZY, Zhang J, Jin L,Wang JC, Wang MH. Genetic variant of miR-4293 rs12220909 is associated with susceptibility to non-small cell lung cancer in a Chinese Han population. PLOS One.2017;12(4):e0175666.(Corresponding author)

3.Shen FY, Chen JJ, Guo SC, Zhou YH, Zheng YB, Yang YJ, Zhang JJ, Wang XF. Wang CJ, Zhao DM, Wang MY, Zhu ML, Fan LX, Xiang JQ, Xia Y, Wei QY, Jin L, Wang JC, Wang MH. Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population. Tumor Biol.2016 Apr;37(4):4777-4784(Corresponding author)

4.Zhang P, Wang JJ, Lu T, Wang XF, Zheng YB, Guo SC, Yang YJ, Wang MY, Vijay Kumar Kolluri, Qiu LX, Shen FY, Fan LX, Li J, Wang YN, Wei,QY, Jin L, Wang JC, Wang MH. miR-449b rs10061133 and miR-4293 rs12220909 Polymorphisms are associated with decreased esophageal squamous cell carcinoma in a Chinese population. Tumor Biol.2015 112015.Nov;36(11): 8789-8795(Corresponding author)

5.Wang MH, Shim Joong Sup,Li Ruo-Jing, Dang YJ, He QQ,Das Manisha, Liu J, Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer. British Journal of Pharmacology. 2014.Oct,171(19):4478-4489

6.Che JH , Dong J, Zheng YB, Zhu BP,Zhang P, Lu DY,Zhang JJ, Xiao JJ, Wang JG, Gao YZ, Yan XL, Wang MH. Polymorphism in PHD1 gene and risk of non-small cell lung cancer in a Chinese population. Tumor Biol. 2014 Sep;35(9):8921-8925. (Corresponding author)

7.Xiao JJ, Zheng YB, Zhou YH, Zhang P, Wang JG, Shen FY, Fan LX, Vijay Kumar Kolluri, Wang WP, Yan XL, Wang MH. Sulfotransferase SULT1A1 Arg213His Polymorphism with Cancer Risk: A Meta-Analysis of 53 Case-Control Studies. PLOS ONE. 2014 Sep 16;9(9):e106774.(Corresponding author)

8.Lu DY, Mao XH, Zhou YH, Yan XL, Wang WP, Zheng YB, Xiao JJ, Zhang P, Wang JG, Neetika Ashwani, Ding WL, Jiang H, Shang Y, Wang MH. RTN4 3’-UTR Insertion/Deletion Polymorphism and Susceptibility to Non-Small Cell Lung Cancer in Chinese Han Population. Asian Pac J Cancer Prev.2014;15(13):5249-5252 (Corresponding author)

9.Zhang JJ, Huang XW, Xiao JJ, Yang YJ, Zhou YH, Wang XF, Liu QM, Yang JM, Wang MY, Qiu LX,Zheng YB, Zhang P, Li J, Wang YN, Wei QY, Jin L, Wang JC, Wang MH. Pri-miR-124 rs531564 and pri-miR-34b/c rs4938723 Polymorphisms Are Associated with Decreased Risk of Esophageal Squamous Cell Carcinoma in Chinese Populations. PLOS ONE.2014 Jun 19;9(6):e100055.(Corresponding author)

10.Wang MH, Wang WP, Zhang P, Xiao JJ, Wang JG, Huang CQ. Discrimination of the Expression of Paralogous microRNA Precursors That Share the Same Major Mature Form. PLOS ONE.2014 Mar 3;9(3):e90591.

11.Zhang JJ, Zhou JS, Zhang P, Wang WP, Tao SH, Wang MH. A Meta-Analysis of the Association between the hOGG1 Ser326Cys Polymorphism and the Risk of Esophageal Squamous Cell Carcinoma. PLOS ONE.2013 Jun 6;8(6):e65742. (Corresponding author)

12.Xu FQ, Wang WP, Lei C, Liu QM, Qiu H,Vinaydhar Muraleedharan, Zhou B, Cheng HX,Huang ZK, Xu WA,Li BC, Wang MH. Activation of transcriptional activity of HSE by a novel mouse zinc finger protein ZNFD specifically expressed in testis. Mol Cell Biochem.2012 Apr;363(1-2):409-17.(Corresponding author)

13.Yang SR, Wang WP, Lei C, Liu QM, Xu FQ, Xing XW, Chen H, Liu JJ, Wu SL, Wang MH. Localization and characterization of rat transmembrane protein 225 specifically expressed in testis. DNA Cell Biol. 2011, 30: 9-16 (Corresponding author)

14.Liu QM, Yao F, Wang MH, Zhou B, Cheng HX, Wang WP, Jin L, Lin Q, Wang JC. Novel human BTB/POZ domain-containing zinc finger protein ZBTB1 inhibits transcriptional activities of CRE. Mol Cell Biochem. 2011 Nov;357(1-2):405-14.

15.Lei C, Liu QM, Wang WP, Li J, Xu FQ, Liu YZ, Liu JJ, Wu SL, Wang MH. Isolation and characterization of a novel zinc finger gene, ZNFD, activating AP1(PMA) transcriptional activities. Mol Cell Biochem. 2010, 340: 63-71. (Corresponding author)

16.Wang JC, Wang MH, Zhang RM, Zhao ZM Chen J, Luo ZW. A chemiluminescence-based assessment of androgen binding activity in a large pedigree affected with androgen insensitivity syndrome,Luminescence.2007,22: 370–378

17.Wang MH, Luo GM, Li F, Wu SL, Jiang JX, Huang CQ. Isolation and Characterization of a Novel Four-Transmembrane Protein PMP22CD Specifically Expressed in the Testis. Int. J. Mol. Sci. 2006,7, 425-437

18.Wang MH, Wang JC, Zhang Z, Zhao ZM,Zhang RM, Hu XH, Tan T, Luo SJ, Luo ZW. Dissecting phenotypic variation among AIS patients. Biochem Biophys Res Commun. 2005,23;335(2):335-42.

19.Zhang HT, Chen XF, Wang MH, Wang JC, Qi QY, Zhang RM, Xu WQ, Fei QY, Wang F, Cheng QQ, Chen F, Zhu CS, Tao SH, Luo Z. Defective expression of transforming growth factor beta receptor type II is associated with CpG methylated promoter in primary non-small cell lung cancer. Clin Cancer Res. 2004, 1;10(7):2359-67.

20.Qi QY, Wang F, Zhang HT, Wang JC, Xiao HP, Wang MH, Han YF, Zhang RM, Tao SH, Luo ZW. Induced recovery of defective membrane expression of a CC chemokine receptor 5 mutant by phytohemagglutinin. Cell Mol Life Sci. 2003, 60(11):2492-500.

21.Fei QY, Zhang HT, Chen XF, Wang JC, Zhang RM, Xu WQ, Zhang Z, Zou W, Zhang KY, QI QY, Wang MH, Tao sh, Luo Zw. Defected expression of E-cadherin in non-small cell lung cancer. Lung Cancer. 2002,37:147-152  

代表项目

国家自然科学基金(81572923)

国家自然科学基金(81071957)

国家自然科学基金(30700826)

苏大医学发展基金(EE134709)  


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