姓  名:朱一蓓
技术职称:教授
导师类型:硕导
所在学系:免疫学系
学科专业:免疫学
电子邮件:xlyb99@163.com;zhuyibei@suda.edu.cn
研究方向

肿瘤免疫应答的调节

肿瘤免疫治疗

个人简历

教育经历

·             2001.09-2004.06,苏州大学医学院,免疫学系,博士研究生/血液学博士

·             1998.09-2001.06,苏州医学院,免疫学系,硕士研究生/免疫学硕士

·             1989.09-1994.06,苏州医学院,临床医学专业,大学本科/医学学士

 

工作经历

·             2016.08-苏州大学医学部基础医学与生物科学学院  免疫学系教授、硕士生导师

·             2010.07-2016.07,苏州大学医学生物技术研究所,苏州大学医学部基础医学与生物科学学院 免疫学系副教授、硕士生导师

·             2008.08-2010.06,美国匹兹堡大学医学院免疫学系,博士后

·             2001.09-2010.07,苏州大学医学生物技术研究所,助教,讲师

·            1994.08-2001.08江苏常州市第一人民医院,肿瘤科,住院医师

学术成果

(1)      Gao X, Wang X, Yang Q, Zhao X, Wen W, Li G, Lu J, Qin W, Qi Y, Xie F, Jiang J, Wu C, Zhang X, Chen X, Turnquist H, Zhu Y*, Lu B*.Tumoral Expression of IL-33 Inhibits Tumor Growth and Modifies the Tumor Microenvironment through CD8+ T and NK Cells.J Immunol. 2015 Jan 1;194(1):438-45 (*co-corresponding author)

(2)      Li G*, Yang Q*, Zhu Y*, Wang HR, Chen X, Zhang X, Lu B. T-Bet and EomesRegulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells. PLoS One. 2013 Jun 27;8(6):e67401. (*co-first author)

(3)      Gao X#, Zhu Y#, Li G, Huang H, Zhang G, Wang F, Sun J, Yang Q, Zhang X, Lu B*.TIM-3 Expression Characterizes Regulatory T Cells in Tumor Tissues and Is Associated with Lung Cancer Progression. PLoS One. 2012;7(2):e30676. (*co-first author)

(4)      Chen C*Zhu YB*Shen Y, Zhu YH, Zhang XG, Huang JA.The Increase of Circulating B7-H4-expressing CD68+ Macrophage Correlated with Clinical Parameters ofLung Carcinomas.J Immunother. 2012;35(4):354-8.(*co-first author)

(5)      Zhu Y, Ju S, Chen E, Dai S, Li C, Morel P, Liu L, Zhang X, Lu B. T-bet and eomesodermin are required for T cell-mediated antitumor immune responses. J Immunol. 2010;185(6):3174-83

(6)      Qu QX, Huang Q, Shen Y, Zhu YB, Zhang XG. The increase of circulating PD-L1-expressing CD68(+) macrophage in ovarian cancer.Tumour Biol. 2016 Apr; 37(4): 5031-7. (*co-corresponding author)

(7)      Chen C*, Zhu YB*, Qu QX, Ge Y, Huang JA, Wang Y, Zhang XG. CD40-activated apoptotic tumor cell-pulsed dendritic cell could potentially elicit antitumor immune response: involvement of up-regulation ofB7-H3 expression. J Immunother. 2009;32(1):29-35 (*co-first author)

(8)      Gu T*, Zhu YB*, Chen C, Li M, Chen YJ, Yu GH, Ge Y, Zhou SY, Zhou H, Huang Y, Qiu YH, Zhang XG. Fine-tuned Expression of Programmed Death 1 Ligands in Mature Dendritic Cells Stimulated by CD40 Ligand is Critical for the Induction of an Efficient Tumor Specific Immune. Response.  Cellular & molecular Immunology. 2008;5(1):33-39 (*co-first author)

(9)      Shi LR, Chen LJ, Wu CP, Zhu YB, Xu B, Zhen X, Sun MF, Wen W, Dai XC, Yang M, Lv QS, Lu BF, Jiang JT. PD-1 Blockade Boosts Radiofrequency Ablation–Elicited Adaptive Immune Responses against Tumor. Clin Cancer Res. 2016; 22(5): 1173-1184

(10)  Wang X, Zhao X, Feng C, Weinstein A, Xia R, Wen W, Lv Q, Zuo S, Tang P, Yang X, Chen X, Wang H, Zang S, Stollings L, Denning TL, Jiang J, Fan J, Zhang G, Zhang X, Zhu Y, Storkus W, Lu B.IL-36γ Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses. Cancer Cell. 2015 Sep 14;28(3):296-306. 

(11)  Zhang G, Huang H, Zhu Y, Yu G, Gao X, Xu Y, Liu C, Hou J, Zhang X. A novel subset of B7-H3+CD14+HLA-DR-/low myeloid-derived suppressor cells are associated with progression of human NSCLC.Oncoimmunology. 2015 Mar 6;4(2):e977164.

(12)  Wang Z, Zhu J, Gu H, Yuan Y, Zhang B, Zhu D, Zhou J, Zhu Y, Chen W.The Clinical Significance of Abnormal Tim-3 Expression on NK Cells from Patients withGastric Cancer.Immunol Invest. 2015;44(6):578-89

(13)  Yang Q, Li G, Zhu Y, Liu L, Chen E, Turnquist H, Zhang X, Finn OJ, Chen X, Lu B.IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cellsEur J Immunol. 2011;41(11):3351-60

(14)  Chen L, Zhu Y, Zhang G, Gao C, Zhong W, Zhang X. CD83-stimulated monocytes suppress T-cell immune responses through production of prostaglandin E2.Proc Natl AcadSci U S A. 2011;108(46):18778-83.

(15)  Jiang J, Zhu Y, Wu C, Shen Y, Wei W, Chen L, Zheng X, Sun J, Lu B, Zhang X. Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer. Cancer ImmunolImmunother. 2010;59(11):1707-14.

(16) J u S, Zhu Y, Liu L, Dai S, Li C, Chen E, He Y, Zhang X, Lu B.Gadd45b and Gadd45g are important for anti-tumor immune responses. Eur J Immunol. 2009; 39(11):3010-8
代表项目
  1. 国家自然科学基金面上项目,负性协同刺激分子Tim3PD-1在肿瘤浸润T淋巴细胞共表达的调节及介导肺癌免疫逃逸的机制(31170866),2012.01-2015.12,主持
  2. 国家自然科学基金面上项目,IL-33/ST2途径在CD8+T细胞介导的胃癌肿瘤免疫应答中的作用研究(81273208),2013.01-2016.12,主持
  3. 国家自然科学基金面上项目,IL-33/ST2途径介导肿瘤浸润T淋巴细胞的聚集、代谢和功能的机制研究(31670916),2017.01-2018.12,主持
   4.  苏州市产业技术创新专项(民生科技),鼠抗人TIM-3单克隆抗体的研制及其在肿瘤免疫治疗中的临床应用研究(SS201664),2016.07-2018.06,主持
社会兼职

1.    中国免疫学会终身会员

2.    中国免疫学会青年工作委员会常务委员

3.    江苏省免疫学会第四届理事会副秘书长,常务理事

4. 江苏省免疫学会第二届青年工作委员会主任委员

Copyright ◎ 2012 苏州大学·医学部基础医学与生物科学学院
地址:苏州工业园区仁爱路199号 邮编:215123 电话:65880103 院长信箱:jcsw@suda.edu.cn