姓  名:郭琳
技术职称:副教授
导师类型:硕导
所在学系:生物化学与分子生物学系
学科专业:生物化学与分子生物学
电子邮件:linguo@suda.edu.cn
研究方向

修饰蛋白质组学

膜生物化学

生物材料

 

个人简历

1997-2001 山东曲阜师范大学化学系,理学学士

2001-2007 厦门大学化学系分析化学专业,理学博士

2008-2009 香港浸会大学化学系,博士后

2009-2012 美国圣路易斯华盛顿大学医学院,博士后

2012.11--  苏州大学医学部基础医学与生物科学学院生化系,副教授

学术成果

1. Hongmei Zhang, Chenglong Xu, Jie Liu, Xiaohong Li, Lin Guo*, Xinming Li*. An enzyme-activatable probe with a self-immolative linker for rapid and sensitive alkaline phosphatase detection and cell imaging through a cascade reaction. Chem. Commun. 2015, 51, 7031-7034.

2. Lin Guo, Xu Zhang, Dequan Zhou, Adewole L. Okunade, Xiong Su. Stereospecificity of fatty acid 2-hydroxylase and differential functions of 2-hydroxy fatty acid enantiomers. J. Lipid Res. 2012, 53, 1327-1335

3. Lin Guo, Dequan Zhou, Adewole L. Okunade, Xiong Su. Fatty acid 2-hydroxylase regulates trafficking of GLUT4 and CD36 in adipocytes via generation of chiral specific 2-hydroxy fatty acids. Abstracts of Papers of the American Chemical Society 2011, 241, 54-BIOL.

4. Lin Guo, Dequan Zhou, Kenneth M. Pryse, Adewole L. Okunade, Xiong Su. Fatty acid 2-hydroxylase mediates diffusional mobility of raft-associated lipids, GLUT4 level, and lipogenesis in 3T3-L1 adipocytes. J. Biol. Chem. 2010, 285, 25438-25447.

5. Lin Guo, Han-Zhi Wu, Hao Yue, Shu-Hai Lin, Yong-Quan Lai, Zong-Wei Cai. A novel and specific method for the determination of aristolochic acid-derived DNA adducts in exfoliated urothelial cells by using ultra performance liquid chromatography-triple quadrupole mass spectrometry. J. Chromatogr. B 2011, 879, 153-158.

6. Lin Guo, Hao Yue, Zong-Wei Cai. A novel pre-column fluorescent derivatization method for the sensitive determination of aristolochic acids in medicinal herbs by high-performance liquid chromatography with fluorescence detection. J. Pharm. Biomed. Anal. 2010, 53, 37-42.

代表项目

1.  国家自然科学基金:基于蛋白质组学和脂质组学研究脂肪酸2-羟化酶调控肿瘤细胞能量代谢的分子机制(31770887),2018/01-2021/12,主持

2.  国家自然科学基金:基于蛋白质突变体和同位素标记技术的双重内标法棕榈酰化蛋白质组定量分析(21305099),2014/01-2017/12,主持

3.  江苏省自然科学基金:基于质谱技术的棕榈酰化蛋白质组定量分析方法研究(BK20130290),2013/07-2017/06,主持

 


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