姓  名:谢芳
技术职称:副教授
所在学系:病理学与病理生理学系
学科专业:病理学
电子邮件:xiefang@suda.edu.cn
研究方向

肿瘤病理

肿瘤免疫

个人简历

1989年9月-1994年7月   苏州医学院临床医学系             本科 临床专业

1994年9月-至今    苏州大学医学部病理与病理生理系    助教、讲师、副教授

1998年9月-2000年7月  苏州大学医学院病理教研室            硕士研究生

2003年9月-2006年10月   苏州大学生命科学学院               博士研究生

2010年7月-2012年7月  University of Michigan Cancer Center   Research Fellow
学术成果

1. He Shan, Wang Ji, Kato K, Xie Fang, Varambally S, Mineishi S, Kuick R, Mochizuki K, Liu Y, Nieves E, Mani RS, Chinnaiyan AM, Marquez VE, Zhang Y. Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells. Blood. 2012;119(5):1274-1282. (排名第四)

2. Wang Z, Shi Q, Wang Z, Gu Y, Shen Y, Sun M, Deng M, Zhang H, Fang J, Zhang S, Xie F. Clinicopathologic correlation of cancer stem cell markers CD44, CD24, VEGF and HIF-1α in ductal carcinoma in situ and invasive ductal carcinoma of breast: an immunohistochemistry-based pilot study. Pathol Res Pract. 2011;207(8):505-513. (通讯作者)

3. Huang Q, Qu QX, Xie F, Hu JM, Chen YG, Zhang XG. Sensitization of SiHa cell to gemcitabine by CD40 activation and its overexpression in cervical carcinoma. Med Oncol. 2011;28(3):781-788. (排名第三)

4. Huang Q, Qu QX, Xie F, Zhang T, Hu JM, Chen YG, Zhang XG. CD40 is overexpressed by HPV16/18-E6 positive cervical carcinoma and correlated with clinical parameters and vascular density. Cancer Epidemiol. 2011;35(4):388-392. (排名第三)

5. Qin W, Hongya W, Yongjing C, Fang X, Yue M, Xuekun Z, Xiaozhong L, Xueguang Z. Increased OX40 and soluble OX40 ligands in children with Henoch-Schonlein purpura: association with renal involvement. Pediatr Allergy Immunol. 2011;22(1 Pt 1):54-59. (排名第四)

6. Fang Xie, Qin Shi, Qin Wang, Yan Ge, Yongjing Chen, Jianling Zuo,Yongping Gu, Haizhen Deng, Hui Mao, Zhenhua Hu, Yinghui Zhou, Xueguang Zhang. CD40 is a regulator for vascular endothelial growth factor in the tumor microenvironment of glioma. J Neuroimmunol. 2010;222(1-2):62-69.(排名第一)

7. Fang Xie, Qin Wang, Yongjing Chen, Yongping Gu, Hui Mao, Wang Zeng, Xueguang Zhang. Costimulatory molecule OX40/OX40L expression in ductal carcinoma in situ and invasive ductal carcinoma of breast: an immunohistochemistry-based pilot study. Pathol Res Pract. 2010;206(11):735-739.(排名第一)

8 Wang Q, Chen Y, Xie F, Ge Y, Wang X, Zhang X. A novel agonist anti-human OX40L monoclonal antibody that stimulates T cell proliferation and enhances cytokine secretion. Hybridoma, 2009; 28(4): 269-276. (排名第三)

9. Cheng Z, Zhou S, Wang X, Xie F, Wu H, Liu G, Wang Q, Chen Y, Hu Y, Lu B, Zhang X. Characterization and application of two novel monoclonal antibodies against human CXCR4: cell proliferation and migration regulation for glioma cell line in vitro by CXCR4/SDF-1alpha signal. Hybridoma (Larchmt). 2009;28(1):33-41. (排名第四)

10. Zhou YH, Chen YJ, Ma ZY, Xu L, Wang Q, Zhang GB, Xie F, Ge Y, Wang XF, Zhang XG. 4IgB7-H3 may be the Major Isoform Expressed on Immmunocytes as well as Malignant Cells. Tissue Antigens, 2007;70(2):96-104. (排名第七)

11. Sun WP, Wang FM, Xie F, Wang GQ, Sun J, Yu GH, Qiu YH, Zhang XG. A novel anti-human syndecan-1 (CD138) monoclonal antibody 4B3: characterization and application. Cell Mol Immunol. 2007;4(3):209-214. (排名第三)

12. Xie F, Wang Q, Chen YJ, Gu Y, Shi Q, Ge Y, Yu G, Wu H, Mao Y, Wang X, Zhou Y, Zhang X. Characterization and application of two novel monoclonal antibodies against human OX40: costimulation of T cells and expression on tumor as well as normal gland tissues. Tissue Antigens, 2006; 67(4): 307-317. (排名第一)

13. Qin Wang, Yongjing Chen, Fang Xie, Yan Ge, Lei Chen, Hongya Wu, Qiuxia Qu, Xuefeng Wang and Xueguang Zhang. Development of a sandwich ELISA assay for evaluating soluble OX40L (CD252) in human sera of different ages or with Graves’ disease. Cytokine, 2006; 36(2): 23-28. (排名第四)

代表项目

国家基金面上项目: OX40/OX40L分子在乳腺癌细胞及组织中的表达和OX40信号对乳腺癌的生物学效应及其分子机制(30672390)

起止时间: 2007.01-2009.12

经费:25万

项目主持人。

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