姓  名:张国兴
技术职称:教授
导师类型:硕导
所在学系:生理学系
学科专业:生理学
电子邮件:zhangguoxing@suda.edu.cn
研究方向

心血管生理

氧化应激

个人简历

1988年9月-1993年6月    学士,江苏大学医学技术学院

1993年9月-2000年12月   检验师,江苏省苏州市中医院检验科

2001年1月-2002年3月    研究生,日本香川大学医学部药理科

2002年4月-2006年4月    博士,日本香川大学医学部药理科

2006年4月-2006年7月    外国人研究者,日本香川大学医学部药理科

2006年8月-2008年3月    助教,日本香川大学医学部药理科

2008年4月-2011年3月    助教,日本奈良医科大学第二生理学科

2011年4月-至今         教授,苏州大学医学部基础医学与生物科学学院

学术成果

1.        Zhang GX, Obata K, Takeshita D, Mitsuyama S, Nakashima T, Kikuta A, Hirabayashi M, Tomita K, Vetter R, Dillmann WH, Takaki M.。Evaluation of left ventricular mechanical work and energetics of normal hearts in SERCA2a transgenic rats. J Physiol Sci. 2012;62(3):221-31. 

2.        Hattori H, Takeshita D, Takeuchi A, Kim B, Shibata M, Matsuoka S, Obata K, Mitsuyama S, Zhang GX, Takaki M. NHE-1 blockade reversed changes in calcium transient in myocardial slices from isoproterenol-induced hypertrophied rat left ventricle. Biochem Biophys Res Commun. 2012;419(2):431-5.

3.        Shibata M, Takeshita D, Obata K, Mitsuyama S, Ito H, Zhang GX, Takaki M. NHE-1 participates in isoproterenol-induced downregulation of SERCA2a and development of cardiac remodeling in rat hearts. Am J Physiol Heart Circ Physiol. 2011;301(5):H2154-60.

4.        Takaki M, Misawa H, Matsuyoshi H, Kawahara I, Goto K, Zhang GX, Obata K, Kuniyasu H. In vitro enhanced differentiation of neural networks in ES gut-like organ from mouse ES cells by a 5-HT(4)-receptor activation. Biochem Biophys Res Commun. 2011; 406: 529-533,

5.        Chen K, Yu X, Murao K, Imachi H, Li J, Muraoka T, Masugata H, Zhang GX, Kobayashi R, Ishida T, Tokumitsu H. Exendin-4 regulates GLUT2 expression via the CaMKK/CaMKIV pathway in a pancreatic beta-cell line. Metabolism. 2011; 60: 579-585.

6.        Yu X, Murao K, Imachi H, Li J, Nishiuchi T, Dobashi H, Hosomi N, Masugata H, Zhang GX, Iwama H, Ishida T. The transcription factor prolactin regulatory element-binding protein mediates prolactin transcription induced by thyrotropin-releasing hormone in GH3 cells. Endocrine. 2010; 38: 53-59,

7.        Zhang GX, Kimura S, Murao K, Yu X, Obata K, Matsuyoshi H, Takaki M. Effects of AT1 Receptor Blockade on the Cardiac Raf/MEK/ERK Cascade Activated via Adrenergic Receptors. J Pharmacol Sci. 2010; 113: 224-233.

8.        Yoshikawa Y, Zhang GX, Obata K, Matsuyoshi H, Asada K, Taniguchi S, Takaki M. A cardioprotective agent of a novel calpain inhibitor, SNJ-1945 exerts {beta}1-actions on left ventricular mechanical work and energetics. Am J Physiol Heart Circ Physiol. 2010; 299: H396-401.

9.        Matsuyoshi H, Kuniyasu H, Okumura M, Misawa H, Katsui R, Zhang GX, Obata K, Takaki M. A 5-HT(4)-receptor activation-induced neural plasticity enhances in vivo reconstructs of enteric nerve circuit insult. Neurogastroenterol Motil. 2010; 22: 806-813.

10.    Yu X, Murao K, Imachi H, Li J, Nishiuchi T, Hosomi N, Masugata H, Zhang GX, Iwama H, Ishida T. Hyperglycemia Suppresses ABCA1 Expression in Vascular Smooth Muscle Cells. Horm Metab Res. 2010; 42: 241-246.

11.    Yoshikawa Y, Zhang GX, Obata K, Ohga Y, Matsuyoshi H, Taniguchi S, Takaki M.  Cardioprotective effects of a novel calpain inhibitor, SNJ-1945 for reperfusion injury after cardioplegic cardiac arrest. Am J Physiol Heart Circ Physiol. 2009; 298: H643-651.

12.    Zhang GX, Kimura S, Murao K, Obata K, Matsuyoshi H, Takaki M. Inhibition of cytochrome c release by 10-N-nonyl acridine orange, a cardiolipin-specific dye, during myocardial ischemia/reperfusion in the rat. Am J Physiol Heart Circ Physiol. 2009; 298: H433-439.

13.    Li J, Murao K, Imachi H, Masugata H, Iwama H, Tada S, Zhang GX, Kobayashi R, Ishida T, Tokumitsu H. Exendin-4 regulates pancreatic ABCA1 transcription via CaMKK/CaMKIV pathway. J Cell Mol Med. 2010; 14: 1083-1087.

14.    Nakajima-Takenaka C, Zhang GX, Obata K, Tohne K, Matsuyoshi H, Nagai Y, Nishiyama A, Takaki M. Left ventricular function of isoproterenol-induced hypertrophied rat hearts perfused with blood: mechanical work and energetics. Am J Physiol Heart Circ Physiol. 2009; 297: H1736-1743.

15.    Murao K, Li J, Imachi H, Muraoka T, Masugata H, Zhang GX, Kobayashi R, Ishida T, Tokumitsu H. din-4 regulates glucokinase expression by CaMKK/CaMKIV pathway in pancreatic beta-cell line. Diabetes Obes Metab. 2009; 11: 939-946.

16.    Lu XM, Zhang GX, Yu YQ, Kimura S, Nishiyama A, Matsuyoshi H, Shimizu J, Takaki M. The opposite roles of nNOS in cardiac ischemia-reperfusion-induced injury and in ischemia preconditioning-induced cardioprotection in mice. 2009; J Physiol Sci. 59:253-262.

17.    Zhang GX, Kimura S, Murao K, Shimizu J, Matsuyoshi H, Takaki M. Role of neuronal NO synthase in regulating vascular superoxide levels and mitogen-activated protein kinase phosphorylation. Cardiovasc Res. 2009; 81: 389-399.

18.    Miyata K, Hitomi H, Guo P, Zhang GX, Kimura S, Kiyomoto H, Hosomi N, Kagami S, Kohno M, Nishiyama A. Possible involvement of Rho-kinase in aldosterone-induced vascular smooth muscle cell remodeling. Hypertens Res. 2008; 31: 1407-1413.

19.    Diah S, Zhang GX, Nagai Y, Zhang W, Gang L, Kimura S, Hamid MR, Tamiya T, Nishiyama A, Hitomi H. Aldosterone induces myofibroblastic transdifferentiation and collagen gene expression through the Rho-kinase dependent signaling pathway in rat mesangial cells. Exp Cell Res. 2008; 314: 3654-3662.

20.    Zhang GX, Lu XM, Kimura S, Nishiyama A. Role of mitochondria in angiotensin II-induced reactive oxygen species and mitogen-activated protein kinase activation. Cardiovasc Res. 2007; 76: 204-212.

21.    Zhang GX, Nagai Y, Nakagawa T, Miyanaka H, Fujisawa Y, Nishiyama A, Izuishi K, Ohmori K, Kimura S. Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases. Am J Physiol Heart Circ Physiol. 2007; 293: H2403-2408.

22.    Zhang GX, Ohmori K, Nagai Y, Fujisawa Y, Nishiyama A, Abe Y, Kimura S. Role of AT1 receptor in isoproterenol-induced cardiac hypertrophy and oxidative stress in mice. J Mol Cell Cardiol. 2007; 42: 804-811.

23.    Rahman M, Nishiyama A, Guo P, Nagai Y, Zhang GX, Fujisawa Y, Fan YY, Kimura S, Hosomi N, Omori K, Abe Y, Kohno M. Effects of adrenomedullin on cardiac oxidative stress and collagen accumulation in aldosterone-dependent malignant hypertensive rats. J Pharmacol Exp Ther. 2006; 318: 1323-1329.

24.    Kimura S, Zhang GX, Nishiyama A, Nagai Y, Nakagawa T, Miyanaka H, Fujisawa Y, Miyatake A, Nagai T, Tokuda M, Abe Y. D-allose, an all-cis aldo-hexose, suppresses development of salt-induced hypertension in Dahl rats. J Hypertens. 2005; 23: 1887-1894.

25.    Miyata K, Rahman M, Shokoji T, Nagai Y, Zhang GX, Sun GP, Kimura S, Yukimura T, Kiyomoto H, Kohno M, Abe Y, Nishiyama A. Aldosterone stimulates reactive oxygen species production through activation of NADPH oxidase in rat mesangial cells. J Am Soc Nephrol. 2005; 16: 2906-2912.

26.    Li FZ, Kimura S, Nishiyama A, Rahman M, Zhang GX, Abe Y. Ischemic preconditioning protects post-ischemic renal function in anesthetized dogs: role of adenosine and adenine nucleotides. Acta Pharmacol Sin. 2005; 26: 851-859.

27.    Kimura S, Zhang GX, Nishiyama A, Shokoji T, Yao L, Fan YY, Rahman M, Suzuki T, Maeta H, Abe Y. Role of NAD(P)H oxidase- and mitochondria-derived reactive oxygen species in cardioprotection of ischemic reperfusion injury by angiotensin II. Hypertension. 2005; 45: 860-866.

28.    Kimura S, Zhang GX, Nishiyama A, Shokoji T, Yao L, Fan YY, Rahman M, Abe Y. Mitochondria-derived reactive oxygen species and vascular MAP kinases: comparison of angiotensin II and diazoxide. Hypertension. 2005; 45: 438-844.

29.    Zhang GX, Kimura S, Nishiyama A, Shokoji T, Rahman M, Yao L, Nagai Y, Fujisawa Y, Miyatake A, Abe Y. Cardiac oxidative stress in acute and chronic isoproterenol-infused rats. Cardiovasc Res. 2005; 65: 230-238.

30.    Kimura S, Zhang GX, Abe Y. Malfunction of vascular control in lifestyle-related diseases: oxidative stress of angiotensin II-induced hypertension: mitogen-activated protein kinases and blood pressure regulation. J Pharmacol Sci. 2004; 96: 406-410.

31.    Kimura S, Zhang GX, Nagai Y, Miyata K, Nishiyama A, Shokoji T, Yao L, Fan YY, Rahman M, Fujisawa Y, Miyatake A, Abe Y. Time-dependent transition of tempol-sensitive reduction of blood pressure in angiotensin II-induced hypertension. J Hypertens. 2004; 22: 2161-2168.

32.    Yao L, Kobori H, Rahman M, Seth DM, Shokoji T, Fan Y, Zhang GX, Kimura S, Abe Y, Nishiyama A Olmesartan improves endothelin-induced hypertension and oxidative stress in rats. Hypertens Res. 2004; 27: 493-500.

33.    Nishiyama A, Yoshizumi M, Rahman M, Kobori H, Seth DM, Miyatake A, Zhang GX, Yao L, Hitomi H, Shokoji T, Kiyomoto H, Kimura S, Tamaki T, Kohno M, Abe Y. Effects of AT1 receptor blockade on renal injury and mitogen-activated protein activity in Dahl salt-sensitive rats. Kidney Int. 2004; 65: 972-981.

34.    Rahman M, Kimura S, Nishiyama A, Hitomi H, Zhang GX, Abe Y. Angiotensin II stimulates superoxide production via both angiotensin AT1A and AT1B receptors in mouse aorta and heart. Eur J Pharmacol. 2004; 485: 243-249.

35.    Zhang GX, Kimura S, Nishiyama A, Shokoji T, Rahman M, Abe Y. ROS during the acute phase of Ang II hypertension participates in cardiovascular MAPK activation but not vasoconstriction. Hypertension. 2004; 43: 117-124.

36.    Nishiyama A, Kobori H, Fukui T, Zhang GX, Yao L, Rahman M, Hitomi H, Kiyomoto H, Shokoji T, Kimura S, Kohno M, Abe Y. Role of angiotensin II and reactive oxygen species in cyclosporine A-dependent hypertension. Hypertension. 2003; 42: 754-760.

37.    Nishiyama A, Fujisawa Y, Fukui T, Rahman M, Kondo N, Ogawa Y, Fanzhu L, Zhang GX, Kimura S, Abe Y. Role of nitric oxide in regional blood flow in angiotensin II-induced hypertensive rats. Hypertens Res. 2001; 24: 421-427.

代表项目

1.       神经性一氧化氮合成酶在心血管疾病中的作用.

2.       性别在缺血-再灌注损伤差异中的机制.

3.       原发性高血压的发病机制.

其  他

1. 2009年, 日本生理学会年度最佳论文

2. 2009年, 日本奈良县立医科大学中岛佐一学术奖

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