姓  名:张雨青
                            技术职称:研究员
                                                    导师类型:博导
                                                     所在学系:应用生物学系
                                                     学科专业:特种经济动物饲养、生物物理
                                                     电子邮件:sericult@suda.edu.cn
研究方向

生物药物与生物医用材料

生物技术与酶工程

个人简历

    一九八一年毕业于苏州蚕桑专科学校(现并入苏州大学),二零零五年三月获日本信州大学大学院工学系研究科生物机能专业工学博士学位。现任苏州大学医学部生物物理专业硕士生导师,特种经济动物饲养专业博士生导师,生药学专业博士生导师。“十一五”、“十二五”期间被农业部聘任为《国家现代农业产业技术体系》茧丝深加工利用岗位科学家。

 

    主要从事丝蛋白新功能材料和蚕桑资源循环利用的研究,特别是以丝蛋白作为酶/药物缓释载体和医用生物材料的研发。参与多个“973”重点项目和农业部公益项目研究,担任国家“863”重大项目课题组副组长并主持课题五研究工作。在国内外学术刊物上发表研究论文100多篇,有4篇论文分别获得1994-95、1996-97、1998-99和2004-05年度苏州市自然科学优秀论文一等奖。申请中国发明专利14项、实用新型2项和国际专利2项;获省级科学技术进步奖六项。1999、2003、2005和2007年分别获苏州大学陆氏科研基金奖、苏州大学大陆产业基金奖、苏州大学苏鑫奖教金科研奖和苏州大学周氏科研类优胜奖。2010年评为苏州大学2010届毕业设计(论文)优秀指导老师。
学术成果


近年发表的主要学术论文(*通讯作者):

1. Min-Hui Wu, Liang-Ze Wan and Yu-Qing Zhang*. A novel sodium N-fatty acyl amino acid surfactant using silkworm pupae as stock material. Scientific Reports. 2014, 4: 4428, DOI: 10.1038/srep04428

 

2. Jin-Ge Zhao, Qian-Qian Yan, Jian Zhang, Yu-Qing Zhang*. Isolation and identification of colorless caffeoyl compounds in purple sweet potato by HPLC-DAD-ESI/MS and their antioxidant activities. Food Chemistry. 2014/accepted.

 

3. Min-Hui Wu and Yu-Qing Zhang*. Ultrafiltration recovery of sericin from silk floss processing alkaline waste and its controlled enzymatic hydrolysis. Journal of Cleaner Production. 2014/accepted

 

4. Ting-Ting Cao, Zhen-Zhen Zhou and Yu-Qing Zhang*. Processing of b-glucosidase-silk fibroin nanoparticle bioconjugates and their characteristics. Appl. Biochem. Biotechnol. 2014/accepted. DOI: 10.1007/s12010-014-0861-y

 

5. Ting-Ting Cao, Yuan-Jing Wang and Yu-Qing Zhang*, Silk reeling of silkworm cocoon in strongly alkaline electrolyzed water as a sericin swelling agent at a lower temperature, Journal of Textile Institute. 2014, 105(5): 502-508. DOI:10.1080/00405000.2013.826418

 

6. Lin Zhu, Yu-Qing Zhang*. Identification and analysis of the pigment composition and sources in the colored cocoon of the silkworm, Bombyx mori, by HPLC-DAD. Journal of Insect Science. 2014, 14:31. http://www.insectscience.org/14.31

 

7. Min-Hui Wu and Yu-Qing Zhang*, Nanofiltration recovery of sericin from silk processing waste and synthesis of a lauroyl sericinbased surfactant and its characteristics. RSC Advances 2014, 4, 4140-4145. DOI: 10.1039/c3ra45549a

 

8. Shu Wang, Meng Fang, Yong-Lei Ma, and Yu-Qing Zhang*, Preparation of the branch bark ethanol extract in mulberry Morus alba, its antioxidation, and antihyperglycemic activity in vivo. Evidence-Based Complementary and Alternative Medicine 2014, Article ID 569652, 7 pages. http://dx.doi.org/10.1155/2014/569652

 

9. Hai-Yan Wang, Yu-Qing Zhang*. Effect of regeneration of liquid silk fibroin on its structure and characterization. Soft Matter 2013, 9:138-145, DOI: 10.1039/c2sm26945g

 

10. Ting-Ting Cao, Yuan-Jing Wang and Yu-Qing Zhang*, Effect of strongly alkaline electrolyzed water on silk degumming and the physical properties of the fibroin fiber, PLOS One 8(6): e65654, 2013. doi:10.1371/journal.pone.0065654.

 

11. Jin-Ge Zhao, Qian-Qian Yan, Li-Zhen Lu and Yu-Qing Zhang*, In vivo antioxidant, hypoglycemic, and anti-tumor activities of anthocyanin extracts from purple sweet potato. Nutr. Res. Pract. 2013. 7(5): 359-365

 

12. Hai-Yan Wang, Yuan-Jing Wang Li-Xia Zhou, Lin Zhu and Yu-Qing Zhang*. Bioactivity of an ethanolic extract from the sericin layer of silkworm Bombyx mori cocoon as a novel functional biomaterial, Food & Function 2012, 3(2), 150-158 DOI: 10.1039/c1fo10148j.

 

13. Yu-Qing Zhang* et al, Highly efficient processing of silk fibroin nanoparticle-Lasparaginase bioconjugates and their characterization as a drug delivery system. Soft Matter 7(20): 9728-9736, 2011. DOI: 10.1039/c0sm01332c

 

14. Lin Zhu, Ren-Ping Hu, Hai-Yan Wang, Yuan-Jing Wang and Yu-Qing Zhang*. Bioconjugation of neutral protease on silk fibroin nanoparticles and application in the controllable hydrolysis of sericin. Journal of Agriculture and Food Chemistry 59(18): 10298–10302, 2011. DOI: 10.1021/jf202036v

 

15. Yu-Qing Zhang* et al, Mechanism of fluorescent cocoon sex identification for silkworms Bombyx mori. Science China Life Sciences 53(11)1330-1339, 2010. DOI: 10.1007/s11427-010-4084-3#page-1

 

16. Li-Zhen Lu, Yu-Zhen Zhou, Yu-Qing Zhang* et al, Anthocyanin extracts from purple sweet potato by means of microwave baking and acidified electrolyzed water and their antioxidation in vitro. Int. J. Food Sci. Technol. 45(7): 1378–1385, 2010

 

17. Hai-Bo Yan, Yu-Qing Zhang* et al, Biosynthesis of insulin-silk fibroin nanoparticles conjugates and in vitro evaluation of a drug delivery system, Journal of Nanoparticle Research 11(8): 1937-1946, 2009. DOI:10.1007/s11051-008-9549-y

 

18. 张雨青等,丝素纳米颗粒的制备及应用于L-天冬酰胺酶的固定化,高等学校化学学报 29(3): 628~633, 2008.

 

19. Yu-Qing Zhang* et al, Formation of silk fibroin nanoparticles in water-miscible organic solvent and their characterization, Journal of Nanoparticle Research 9(5): 885-900, 2007. DOI: 10.1007/s11051-006-9162-x

 

20. Yu-Qing Zhang* et al, Silk sericin-insulin bioconjugates: synthesis, characterization and biological activity, Journal of Controlled Release 115: 307-315, 2006.

 

获奖:

1.  2013年度《丝胶回收与综合利用关键技术及产业化》获国家科技进步二等奖,排名第五(2013-J-212-2-03-R05)

2.  2012年度《荧光判性家蚕新品种的育成及雄蚕丝的开发》获教育部科学技术进步二等奖,排名第九(1-2-9)

3.  2003年度《纳米丝素中SOD固定化研究及其纳米产品》获第八届“挑战杯”全国大学生课外学术科技作品竞赛二等奖,指导教师

4.  2002年度《利用Bm-NPV表达丙型肝炎病毒抗原蛋白》获苏州市科技进步二等奖,排名第五(No.2-22-5)

5.  2000年度《以固定化酶丝素膜为基础的葡萄糖尿酸生物传感器的研究》获江苏省科技进步三等奖,排名第一(No.3-51-1)

6.  1995年度《珍珠漂白工艺(中试)》获江苏省科技进步四等奖,排名第三(No.4-2 -3)

 

专利:

1.  张雨青等,一种蚕丝脱胶/精练剂及其应用,发明专利,CN103205885A, 2013-7-17

2.  张雨青等; 一种利用强碱性电解水低温缫丝的方法,发明专利,CN102605436A, 2012-7-25

3.  张雨青等,一种柱层析上样装置,发明专利,CN101923078A1, 2012-11-06

4.  张雨青等,一种桑树枝条剥皮机,发明专利,CN101811318 (A), 2010-08-25

5.  张雨青等,一种护肤用蚕丝扑粉的制备及使用方法,发明专利,CN101780024A, 2010-7-21

6.  张雨青等,一种从紫甘薯中提取花色苷的方法,发明专利,CN101735644A, 2010-6-16

7.  张雨青等,一种蚕茧丝胶层醇溶物及其制备方法,发明专利,200910027117.8; 2011-4-13授权

8.  张雨青等,一种具有降血糖活性的桑皮提取物及其制备方法,发明专利,CN10133694A;2009-1-7

9.  Yu-Qing Zhang. A method of producing nanosize fibroin particle, PCT, WO 2005085327 A1, 2005. 9. 15.

Yu-Qing Zhang. Silk fibroin nanoparticles fixed with enzyme and their production, PCT, WO2007112679A1, 2007.10.11.  



代表项目


1.  十二·五国家现代农业产业技术体系《茧丝深加工利用岗位》,2011-2015,350万元,主持;

2.  十一·五国家现代农业产业技术体系《蚕茧深加工岗位》,2008-2010,210万元,主持;

3.  国家高技术研究发展计划(863)计划《家蚕基因表达谱和蛋白质组研究》, 2006-2010,担任课题组副组长,课题五,83万元,主持