姓  名:庄文卓
 技术职称:副教授
 导师类型:硕导
 所在学系:基础医学与生物科学学院
 学科专业:细胞生物学
 电子邮件:zhuangwenzhuo@suda.edu.cn
研究方向

肿瘤细胞生物学  

个人简历


1992/09-1997/06,吉林大学医学部(原白求恩医科大学),获学士学位

2000/09-2003/06,吉林医学院,获硕士学位

2003/08-至今,苏州大学细胞生物学系,助教,讲师,副教授

2008/09-2011/06,苏州大学获博士学位

2012/03-2013/05,美国德州大学MD Anderson癌症中心淋巴瘤/骨髓瘤系,博士后研究  





学术成果



近几年第一作者或通讯作者发表文章:


1、Xu H, Han H, Song S, Yi N, Qian C, Qiu Y, Zhou W, Hong Y, Zhuang W, Li Z, Li B, Zhuang W (corresponding author). Exosome-Transmitted PSMA3 and PSMA3-AS1 Promotes Proteasome Inhibitors Resistance in Multiple Myeloma. Clin Cancer Res. 2019 Jan 4.


2、Li B, Han H, Song S, Fan G, Xu H, Zhou W, Qiu Y, Qian C, Wang Y, Yuan Z, Gao Y, Zhang Y, Zhuang W (corresponding author). HOXC10 Regulates Osteogenesis of Mesenchymal Stromal Cells through Interaction with its Natural Antisense Transcript lncHOXC-AS3. Stem Cells. Stem Cells. 2019 Feb;37(2):247-256.


3、Gu J, Song S, Han H, Xu H, Fan G, Qian C, Qiu Y, Zhou W, Zhuang W(corresponding author), Li B. The BET Bromodomain Inhibitor OTX015 Synergizes with Targeted Agents in Multiple Myeloma. Mol Pharm. 2018 Nov 5;15(11):5387-5396.


4、Shi J, Song S, Han H, Xu H, Huang M, Qian C, Zhang X, Ouyang L, Hong Y, Zhuang W (corresponding author), Li B. Potent Activity of the Bromodomain Inhibitor OTX015 in Multiple Myeloma. Mol Pharm. 2018 Sep 4;15(9):4139-4147.


5、Li B, Xu H, Han H, Song S, Zhang X, Ouyang L, Qian C, Hong Y, Qiu Y, Zhou W, Huang M, Zhuang W (corresponding author). Exosome-Mediated Transfer of lncRUNX2-AS1 from Multiple Myeloma Cells to MSCs Contributes to Osteogenesis. Oncogene. 2018 Oct;37(41):5508-5519.


6、Zhang X, Li B, Han H, Song S, Xu H, Yi Z, Hong Y, Zhuang W (corresponding author), Yi N. Pathway-Structured Predictive Modeling for Multi-Level Drug Response in Multiple Myeloma. Bioinformatics. 2018 Nov 1;34(21):3609-3615.

 

7、Zhang X, Li B, Han H, Song S, Xu H, Hong Y, Yi N, Zhuang W (corresponding author). Predicting Multi-Level Drug Response with Gene Expression Profile in Multiple Myeloma Using Hierarchical Ordinal Regression. BMC Cancer. 2018 May 10;18(1):551.


8、Zhuang W, Ge X, Yang S, Huang M, Zhuang W, Chen P, Zhang X, Fu J, Qu J, Li B. Upregulation of lncRNA MEG3 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells from Multiple Myeloma Patients by Targeting BMP4 Transcription. Stem Cells. 2015 Jun;33(6):1985-97..


9、Li B, Chen P, Qu J, Shi L, Zhuang W, Fu J, Li J, Zhang X, Sun Y, Zhuang W (corresponding author).Activation of LTBP3 Gene by a Long Noncoding RNA (lncRNA) MALAT1 Transcript in Mesenchymal Stem cells from Multiple Myeloma. J Biol Chem. 2014 Oct 17;289(42):29365-75.


10、Zhuang W, Long L, Zheng B, Ji W, Yang N, Zhang Q, Liang Z. Curcumin Promotes Differentiation of Glioma-initiating Cells by Inducing Autophagy. Cancer Sci. 2012 Apr;103(4):684-90.


11、Zhuang W, Li B, Long L, Chen L, Huang Q, Liang Z. Induction of Autophagy Promotes Differentiation of Glioma-initiating Cells and their RadiosensitivityInt J Cancer. 2011 Dec 1;129(11):2720-31.


12、Li B, Fu J, Chen P, Zhuang W (corresponding author). Impairment in Immunomodulatory Function of Mesenchymal Stem Cells from Multiple Myeloma Patients. Arch Med Res. 2010 Nov;41(8):623-33.


13、Zhuang W, Li B, Long L, Chen L, Huang Q, Liang ZQ. Knockdown of the DNA-dependent Protein Kinase Catalytic Subunit Radiosensitizes Glioma-initiating Cells by Inducing Autophagy. Brain Res. 2011 Jan 31;1371:7-15.


14、Zhuang W, Qin Z, Liang Z. The Role of Autophagy in Sensitizing Malignant Glioma Cells to Radiation Therapy. Acta Biochim Biophys Sin (Shanghai). 2009 May;41(5):341-51. Review.





代表项目

作为主持人承担国家自然基金面上项目和江苏省自然科学基金面上项目各一项。